拉米的长期治疗能使E抗原阴性的HBV纤维化减退

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Prolonged Lamivudine Therapy Results in Regression of Cirrhosis Associated with Hepatitis B e (HBe) Antigen-negative Chronic Hepatitis B


In theory, hepatic fibrosis should be a dynamic process with the potential for remodeling after the injury-provoking stimulus has been removed.

Clinically, there has been an accumulation of a small number of cases, including hepatitis B e (HBe) antigen-positive chronic hepatitis B infection, in which cirrhosis regressed after successful treatment.

The current report from the University of British Columbia describes a 42-year-old HBe antigen-negative Chinese man with detectable serum hepatitis B virus DNA and histologically established cirrhosis (Ludwig score 4) who, after 4 years of successful lamivudine (Epivir-HBV) therapy, was found to have regression of cirrhosis on repeat liver biopsy.

The repeat biopsy revealed normal liver architecture with fibrosis confined to the portal tracts and short fibrosis septae extending into the lobule without bridging (Ludwig score 1-2).

The authors conclude, 揂lthough cirrhosis may take many years to develop, our experience suggests that successful treatment may reverse the process within a relatively short time.?/span>

Department of Medicine, University of British Columbia, Vancouver, BC, Canada.

10/04/04

Reference
E M Yoshida and others. Regression of cirrhosis associated with hepatitis B e (HBe) antigen-negative chronic hepatitis B infection with prolonged lamivudine therapy. European Journal of Gastroenterology and Hepatology 16(3): 355-358. March 2004.

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大排长

看来我的拉米还是有必要继续吃下去的。抗纤维化也是一个重要的目的。