Vaccine

OCD

Vaccine. 2003 Sep 8;21(25-26):3789-94.

Analysis of anti-HBs levels in healthcare workers over 10 years following
booster vaccination for hepatitis B virus.

Nakao K, Hamasaki K, Wakihama N, Maeda M, Ohtsubo N, Sagiike T, Ichikawa T,
Ishikawa H, Eguchi K, Ishii N.

Health Research Center, Nagasaki University, 1-7-1, Sakamoto, 852-8501,
Nagasaki, Japan

In this study, we analyzed anti-HBs levels in 104 Japanese healthcare
workers who received three booster HBV surface antigen (HBsAg) vaccines
because 80 became anti-HBs-negative at a mean of 2.4 years after the primary
vaccination and 24 did not respond to primary vaccination. Of the
re-vaccinees, 96% achieved a level of 10mIU/ml or more of anti-HBs (i.e.
seroprotected), 1 month after booster vaccination. Although anti-HBs levels
of re-vaccinees decreased as rapidly as those of primary immunized
vaccinees, at 10 years post-booster, 64% of re-vaccinees maintained anti-HBs
levels at 10mIU/ml or higher. Our results suggest that the additional
three-dose protocol of booster HBsAg vaccination is beneficial in
maintaining a seroprotective level of anti-HBs until new immunogenic
vaccination protocols are established.

PMID: 12922112 [PubMed - in process]