Prediction of liver histological lesions

liver411

[B]with biochemical markers in patients with chronic hepatitis B.[/B] J Hepatol. 2003 Aug;39(2):222-30. Links Myers RP, Tainturier MH, Ratziu V, Piton A, Thibault V, Imbert-Bismut F, Messous D, Charlotte F, Di Martino V, Benhamou Y, Poynard T. Department of Hepatology and Gastroenterology, Groupe Hospitalier Pitie-Salpetriere, Paris, France BACKGROUND AIMS: Liver biopsy is the gold standard for assessing hepatitis B virus (HBV)-related histology. The aim was to determine the diagnostic utility of noninvasive serum markers in patients with chronic hepatitis B.METHODS: The aminotransferases and indices including alpha(2)-macroglobulin, apolipoprotein A1, haptoglobin, gamma-glutamyl-transpeptidase (GGT), and total bilirubin (Fibrotest), and ALT (Actitest) were compared with liver histology. The primary outcomes were A2-A3 activity and F2-F4 fibrosis (METAVIR).RESULTS: Two hundred and nine patients were included. Forty-one patients (20%) had A2-A3 activity and 61 (29%) had F2-F4 fibrosis. AST and GGT (P<0.001) were independently associated with A2-A3 activity. AST, ALT, and Actitest accurately predicted activity ((areas under receiver operating characteristic (ROC) curves (AUROC), 0.81-0.82+/-0.04)); an AST or ALT0.80 had negative and positive predictive values of 92%, respectively. Restricting biopsy to patients with intermediate scores (>0.20 and

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慢性肝炎患者生物化学标记对肝脏组织学损害的预示

雪绒花

背景目标：肝活检是评定与乙肝病毒有关的组织学的黄金标准。目的是确定对慢性肝炎患者血清标志变化的诊断效果。

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B.METHODS: The aminotransferases and indices including
alpha(2)-macroglobulin, apolipoprotein A1, haptoglobin,
gamma-glutamyl-transpeptidase (GGT), and total bilirubin (Fibrotest), and
ALT (Actitest) were compared with liver histology.
方法：转氨酶和包括阿尔法巨球蛋白、阿朴脂蛋白A1、结合珠蛋白、咖吗转肽酶、总胆红素的指针，并且把谷丙转氨酶做为肝脏组织学的比较。