|
- 现金
- 222032 元
- 精华
- 285
- 帖子
- 67620
- 注册时间
- 2001-11-10
- 最后登录
- 2023-5-7
|
1楼
发表于 2002-10-21 17:46
Journal of Gastroenterology and Hepatology
Volume 17 Issue 11 Page 1198 - November 2002
INJECTION THERAPY FOR CHRONIC VIRAL HEPATITIS
Efficacy of Stronger Neo-Minophagen C compared between two doses
administered three times a week on patients with chronic viral hepatitis
Kazuhiko Miyake,* Toshiro Tango, Yasuhiko Ota, Keiji Mitamura, Makoto
Yoshiba, Makoto Kako,**, Shigeki Hayashi, Yusei Ikeda, Norimasa Hayashida, Shogo Iwabuchi,, **** Yuzuru Sato,*** Toshiaki Tomi, Naoya Funaki, Naoaki Hashimoto, Tomoyuki Umeda, Jun Miyazaki,**** Katsuaki Tanaka, Yasuo Endo and Hiroshi Suzuki
Abstract
Background: A daily injection of glycyrrhizin (Stronger Neo-Minophagen C
(SNMC) containing 40 mg glycyrrhizin in a 20 mL ampoule) lowers alanine
aminotransferase (ALT) levels in patients with chronic viral hepatitis.
Methods: The therapeutic effects of intermittent administration of SNMC
three times a week for 12 weeks were evaluated and compared between two doses (40 and 100 mL) in a randomized clinical trial.
Results: Overall, the therapeutic response was better in the 53 patients
allocated 100 mL than the 59 who were allocated to have 40 mL SNMC (P =
0.0243). At the completion of SNMC treatment, ALT levels decreased more
extensively in the patients on 100 mL than those on 40 mL SNMC (29 vs50% in comparison with the baseline value, P = 0.0002). Minor side-effects occurred in both the patients on 100 mL (20%) and those on 40 mL (12%), but they did not require any therapies.
Conclusions: Intermittent SNMC would be efficient in suppressing ALT levels in patients with chronic viral hepatitis in a dose-dependent manner. Taken along with infrequent and very mild side-effects, long-term intermittent SNMC would benefit patients with chronic hepatitis by maintaining their quality of life with easier compliance.
© 2002 Blackwell Publishing Asia Pty Ltd
|
|
