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发表于 2002-9-4 09:35
For Liver Cirrhosis,
Conventional treatment is supportive, since cure is unlikely: withdrawal of alcohol and other toxic agents, correction of nutritional deficiencies, and treatment of complications as they arise. A number of experimental drugs are being investigated for reversal of liver damage, but few have proven effective. Liver transplantation for patients with advanced disease has dramatically increased the life expectancy associated with liver cirrhosis.
An extract of milk thistle (Silybum marianum) that is high in a flavonoid compound known as silymarin may improve liver function and increase survival in people with cirrhosis. Clinical trials have shown that silymarin (420–600 mg per day) improves liver function tests and protects liver cells against oxidative damage in people with alcohol-related liver disease. However, evidence is conflicting regarding the ability of silymarin to prolong survival of people with liver cirrhosis. In one double-blind trial, a significant increase in survival was found in people with cirrhosis who were given 140 mg of silymarin three times a day for approximately two years. Positive results were also found in a 12-month controlled study of adults with diabetes and alcoholic liver cirrhosis taking the same daily amount of silymarin.
For people with chronic liver disease, milk thistle extract may be taken long-term. Milk thistle extracts containing 80% silymarin are commercially available and may be taken in amounts that deliver 420 mg of silymarin per day.
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