Hepatocarcinogenesis in hepatitis viral infection:

liver411

~~lessons from transgenic mouse studies
Date:  Wed, 31 Jul 2002 06:42:51 -0400

J Gastroenterol 2002;37 Suppl 13:55-64

Hepatocarcinogenesis in hepatitis viral infection: lessons from transgenic
mouse studies.

Koike K
Department of Infectious Diseases, Internal Medicine, Graduate School of
Medicine, University of Tokyo, Japan.

[Medline record in process]


Over the past decade, genetically engineered mouse models have been used for studies of the mechanisms underlying human diseases. One advantage of these models is that the targeted protein executes its function in normal cells in
their natural tissue microenvironments. Transgenic mouse models for human
viral hepatitis have also been established and have provided new insights
into the pathogenesis of hepatitis and hepatocellular carcinoma (HCC). In
the search for the mechanism of hepatocarcinogenesis in hepatitis viral
infection, two viral proteins, the core protein of hepatitis C virus (HCV)
and the HBx protein of hepatitis B virus (HBV), have been shown to possess oncogenic potential through transgenic mouse studies, indicating the direct involvement of the hepatitis viruses in hepatocarcinogenesis. The presence of the hepatitis C virus core or HBx protein, which has an oncogenic potential, may allow some of the steps in multistep hepatocarcinogenesis to be skipped. This may explain the very high frequency of HCC in patients with HCV or HBV infection.

PMID: 12109667, UI: 22104076

枯水清源

不错。
不知道HBx是否可以作为HCC药筛靶标