HAART提高生活质量：我们应该关心的精子质量吗？

MP4

http://www.ncbi.nlm.nih.gov/pubmed/17898645
全文：
http://dare.uva.nl/document/130864

Ther Drug Monit. 2007 Oct;29(5):566-70.
Semen quality and drug concentrations in seminal plasma of patients using a didanosine or didanosine plus tenofovir containing antiretroviral regimen.Lowe SH, van Leeuwen E, Droste JA, van der Veen F, Reiss P, Lange JM, Burger DM, Repping S, Prins JM.
SourceDepartment of Internal Medicine, Division of Infectious Diseases, Tropical Medicine and AIDS, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands. [email protected]

AbstractData on the concentrations of didanosine (ddI) and tenofovir (TFV) in seminal plasma are sparse. Subtherapeutic drug concentrations within the lumen of the male genital tract may have implications for selection and transmission of drug-resistant HIV strains. On the other hand, sufficient penetration of these drugs into the male genital tract has potential toxic effects on the spermatozoa and their precursors. In the current study, the authors obtained paired semen and blood samples at variable time points after drug intake from 30 HIV-1-infected patients using a ddI (n = 15) or ddI + TFV (n = 15) containing an antiretroviral regimen. Didanosine and TFV concentrations were measured in seminal and blood plasma and semen quality was assessed. Both ddI and TFV penetrated well into seminal plasma. Whereas blood plasma ddI concentrations dropped to near or below the lower limit of quantification of 0.017 microg/mL 9 hours after drug intake, the ddI concentration in seminal plasma remained detectable during the whole dosing interval with a median of 0.20 and 0.21 microg/mL in the ddI and ddI + TFV groups, respectively. Tenofovir was detectable during the whole dosing interval in both blood and seminal plasma with a median concentration of 0.12 and 0.25 microg/mL, respectively, and a median seminal-to-blood-plasma ratio of 3.3. Semen quality was within the normal range according to the criteria of the World Health Organization, except for the percentage of progressively motile sperm, which was low in both groups of patients. The authors conclude that ddI and TFV penetrate well into seminal plasma and that the reduced sperm motility deserves further study.

MP4

谷歌翻译
进一步药品监视 2007年10月29（5）:566-70。
Semen quality and drug concentrations in seminal plasma of patients using a didanosine or didanosine plus tenofovir containing antiretroviral regimen.精液的质量和使用去羟肌苷或去羟肌苷加替诺福韦含抗逆转录病毒疗法的患者精浆中的药物浓度。
Lowe SH , van Leeuwen E , Droste JA , van der Veen F , Reiss P , Lange JM , Burger DM , Repping S , Prins JM . 洛SH ，： 德罗斯特JA ， 货车Leeuwen E ， 的van der VEEN F ， P赖斯 ， 兰格JM ， 汉堡DM ， Repping小号 ， 普林斯JM 。
Source源 Department of Internal Medicine, Division of Infectious Diseases, Tropical Medicine and AIDS, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.内科，传染病科，热带医学和艾滋病，阿姆斯特丹，荷兰阿姆斯特丹大学学术医疗中心，。 [email protected] [email protected]

Abstract抽象
Data on the concentrations of didanosine (ddI) and tenofovir (TFV) in seminal plasma are sparse.去羟肌苷（DDI）的浓度和替诺福韦（TFV）精浆中的数据是稀疏的。 Subtherapeutic drug concentrations within the lumen of the male genital tract may have implications for selection and transmission of drug-resistant HIV strains.亚治疗男性生殖道管腔内的药物浓度耐药艾滋病病毒毒株的选择和传输的影响。 On the other hand, sufficient penetration of these drugs into the male genital tract has potential toxic effects on the spermatozoa and their precursors.另一方面，足够的渗透进入男性生殖道的这些药物具有潜在的毒性作用在精子和它们的前体。 In the current study, the authors obtained paired semen and blood samples at variable time points after drug intake from 30 HIV-1-infected patients using a ddI (n = 15) or ddI + TFV (n = 15) containing an antiretroviral regimen.在目前的研究中，作者获得配对的精液和血液样本变量的时间点服药后从30一DDI组（n = 15）或ddI + TFV（N = 15），含抗逆转录病毒疗法的HIV-1感染的患者使用。 Didanosine and TFV concentrations were measured in seminal and blood plasma and semen quality was assessed.去羟肌苷和TFV浓度测定精液和血浆和精液质量进行评估。 Both ddI and TFV penetrated well into seminal plasma. ddI和，TFV渗透到精液中。 Whereas blood plasma ddI concentrations dropped to near or below the lower limit of quantification of 0.017 microg/mL 9 hours after drug intake, the ddI concentration in seminal plasma remained detectable during the whole dosing interval with a median of 0.20 and 0.21 microg/mL in the ddI and ddI + TFV groups, respectively.鉴于血浆ddI的浓度下降到接近或低于定量的下限为0.017微克/ mL 9小时后，药物摄入，ddI的精浆浓度仍然检测到在整个给药间隔的中位数为0.20和0.21微克/毫升的去羟肌苷和去羟肌苷+的TFV组，分别。 Tenofovir was detectable during the whole dosing interval in both blood and seminal plasma with a median concentration of 0.12 and 0.25 microg/mL, respectively, and a median seminal-to-blood-plasma ratio of 3.3.替诺福韦的平均浓度为0.12和0.25微克/毫升，分别与在血液和精浆整个给药间隔期间检测到的，和中位数精液血液血浆比3.3。 Semen quality was within the normal range according to the criteria of the World Health Organization, except for the percentage of progressively motile sperm, which was low in both groups of patients.精液质量在正常范围内，根据世界卫生组织的标准，逐步运动能力的精子，这是低，两组患者的百分比除外。 The authors conclude that ddI and TFV penetrate well into seminal plasma and that the reduced sperm motility deserves further study.作者的结论，ddI和TFV渗透到精浆和精子活力降低，值得进一步研究。

全文翻译
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MP4

英语不好，求精准翻译
根据世界卫生组织的标准，精液质量在正常范围内，但精子活力降低？

MP4

其他资料
http://dare.uva.nl/cgi/b/bib/bib-idx?type=boolean&lang=en&c=uvadis&q1=Male%20reproduction%20and%20%20HIV-1%20infection&rgn1=title&op2=And&q2=&rgn2=author&op3=And&q3=&rgn3=entire+record&op6=and&rgn6=faculty&q6=+&op7=and&rgn7=department%2Finstitute&q7=+&op8=and&rgn8=files&date1=2009&date2=2009;sort=publicationyear;cc=uvadis;view=reslist;fmt=long;page=reslist;start=1;size=1

HAART提高生活质量：我们应该关心的精子质量吗？
http://96.127.183.242:8080/xmlui ... 108B.pdf?sequence=1
http://www.eatg.org/news/163722/ ... ity_of_spermatozoa?

http://www.ncbi.nlm.nih.gov/pubmed/18317005
Effects of antiretroviral therapy on semen quality.
抗逆转录病毒疗法对精液质量的影响。
结果： The median period of follow up was 48 weeks (interquartile range 33-52 weeks).随访的中位随访时间为48周（四分位距为33-52周）。 Five patients used thymidine analogue-containing cART, 23 used tenofovir-based cART, six used other regimens. 5例患者使用含胸腺嘧啶脱氧核苷类似物的购物车，23泰诺福韦为基础的车，6个用于其他方案。 At all timepoints the percentage of progressively motile spermatozoa was low according to WHO criteria, and it decreased significantly from 28 to 17% during follow-up (P = 0.02).在所有时间点的逐步运动精子的比例低，根据世界卫生组织的标准，并在随访期间（P = 0.02）显着下降，从28%至17％。 All other semen parameters were in the normal range and remained stable.所有其他的精液参数均在正常范围内，并保持稳定。