阿地福韦长期用药效益和副作用的研究

乙肝别理我1

一万而已呀，如果能治好我出2万，要知道发病的住院费，旷工损失，精神损失等等绝对值肯定比一万多得多。

xb

是呀，我都吃拉迷好几万了呢。要是阿的能帮我恢复正常人样子，我可以去挣呀，至少抢还会有力气，乞讨不会被狗咬。

绿茶女孩

这个药应该不是可以根治的药，只是比拉米要好点而已

unpigdual

只是能解决拉米的变异问题，真正的抗病毒效果不如拉米。

乙肝别理我1

恩提卡呢？是什么情况介绍一下

对蛙类无反感

现在应该讨论一下adevovir和恩替的价格问题。

wishkillhbv

如果能彻底干掉HBV,我愿意出100万，用我剩下的时间赚钱还！

liver411

加拿大的一项研究显示, 对Adefovir Dipivoxil进行了60周乙肝治疗用药结果发现并不会产生抗药(变异)现象.

此外, 服用ADV应该在有知识的医生指导下, 每个月验血(具体有几项必须检查项目, 一时记不起来, 下次去FDA网站时再记下来).

原文简摘:

AUGUST  2002 VIRAL HEPATITIS B- Resistance Surveillance in Chronic Hepatitis B Patients Treated with Adefovir Dipivoxil for up to 60 Weeks

H. Yang (1), C. E. Westland (1), W. E. Delaney IV (1), E. J. Heathcote (2), V. Ho (1), J. Fry (1) , C. Brosgart (1), C. S. Gibbs (1), M. D. Miller (1), S. Xiong (1)

(1) Gilead Sciences Inc., Foster City, CA; (2)Toronto Western Hospital, Toronto, Ontario, Canada.

Current therapies for chronic hepatitis B virus (HBV) infection do not provide adequate long-term control of viral replication in the majority of patients. Monotherapy with nucleoside analogs, such as lamivudine and famciclovir, is effective for short periods but results in the emergence of drug-resistant HBV in a substantial number of patients within 1 year of therapy. Adefovir dipivoxil (ADV) has demonstrated clinical activity against wild-type and lamivudine-resistant HBV, but it is unclear whether resistance mutations will emerge after long-term therapy with this drug. To determine whether extended treatment with ADV led to the emergence of drug-resistant populations of HBV, we analyzed virus isolated from patients currently enrolled in a long-term open-label study. The reverse transcriptase domain of HBV polymerase was amplified and sequenced from patients that had received a cumulative exposure of up to 60 weeks of ADV. During our analyses, several previously unreported amino acid substitutions were observed in the reverse transcriptase domain of HBV. Importantly, none of the observed mutations occurred in more than 1 patient, nor were they associated with an adefovir-resistant phenotype in vitro. Furthermore, none of the patients from whom these mutant viruses were isolated had evidence of virologic rebound. In conclusion, these results, although based on a limited number of patients, suggest that treatment with ADV does not lead to the emergence of resistant virus after up to 60 weeks of therapy. (Hepatology;36,464-473,2002.)


[B](仅作为HBVHBV.COM网友内部交流, 指正)[/B]

cfz5

我们知道阿福大剂量服用有肾毒性，到目前为止看到的消息都说小剂量服用对大部分人是安全的，但长期使用是否有毒性的结累？我一直没看到这方面的资料，现在大家都在对他寄予厚望，小心老外报喜不报忧。

九阴真肝

费用要以一年一万呢？好贵，我们这拉米就不给报，恩梯什么时候能出来呀