标题: The relationship between liver disease stage and liver fibrosis: a tangled web [打印本页] 作者: StephenW 时间: 2011-1-6 22:17 标题: The relationship between liver disease stage and liver fibrosis: a tangled web
The relationship between liver disease stage and liver fibrosis: a tangled web
Authors: Germani, Giacomo1; Burroughs, Andrew K1; Dhillon, Amar P2
Source: Histopathology, Volume 57, Number 6, December 2010 , pp. 773-784(12)
Publisher: Wiley-Blackwell
Abstract:
Germani G, Burroughs A K & Dhillon A P
(2010) Histopathology57, 773-784
The relationship between liver disease stage and liver fibrosis: a tangled web
The structural consequences of chronic liver disease are described as a series
of liver disease `stages' with scarring and architectural change that eventually
destroys and replaces the normal lobular structure of the liver. Fibrosis
(`excess collagen') and stage have been confused in histological staging
systems. Fibrosis is part of increasing liver disease stage, but fibrosis and
stage are different. Staging liver disease is important in routine
histopathological assessment. Measurement of liver fibrosis is another process.
The collagenous proportion of a liver biopsy [collagen proportionate area (CPA)]
correlates with hepatic venous pressure gradient (HVPG), which is of recognized
prognostic value. CPA at 1 year post-transplantation in hepatitis C
virus-infected patients predicts subsequent clinical decompensation. CPA in
cirrhotic patients predicts decompensation more accurately than staging or HVPG.
The `cirrhosis' stage category has poor prognostic power, and CPA effectively
substages cirrhosis. CPA improves the description of liver disease stage. Proper
validation of antifibrotic treatments and `non-invasive markers of liver
fibrosis' requires measurement of liver fibrosis (and not liver biopsy stage
scores). It is unacceptable for the words `fibrosis' and `score' to remain next
to each other. There are benefits to properly understanding liver fibrosis and
liver disease stage and properly assessing each of them.
Document Type: Research article
DOI: 10.1111/j.1365-2559.2010.03609.x
Affiliations: 1: The Royal Free Sheila Sherlock Liver Centre and University
Department of Surgery UCL, Royal Free Hospital 2: Department of Cellular
Pathology, UCL Medical School, Royal Free Campus, London, UK Publication date:
2010-12-01
No, I just use Google Translate, which is less than perfect. Most of the posts are very technical and very difficult to translate. I am open to any reasonable suggestions.
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