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标题: 蜂产品的作用 [打印本页]

作者: lemonades 时间: 2009-9-22 12:07 标题: 蜂产品的作用

The effects of royal jelly on liver damage induced by paracetamol in mice.
Kanbur M, Eraslan G, Beyaz L, Silici S, Liman BC, Altinordulu S, Atasever A.
Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Erciyes, Kayseri, Turkey.

The present study was undertaken to investigate the protective effect of royal jelly against paracetamol-induced liver damage. The study was conducted in 90 female Swiss Albino mice, and six groups were established. While the first group was maintained as control, Groups 2-6 were administered 200mg/kg RJ for 1 day, 200mg/kg RJ for 7 days, 400mg/kg PAR for 1 day, 200mg/kg RJ plus 400mg/kg PAR for 1 day and 200mg/kg RJ for 7 days and then second 400mg/kg PAR on the 7th day, orally, respectively. It was shown that PAR significantly increased serum ALT, AST, ALP, liver MDA levels and significantly decreased liver GSH-Px activity, when compared to the control group (Group 1). On the other hand, meaningful changes were observed in the biochemical parameters of the group which was administered long-term RJ (Group 6). The aforementioned parameters which were statistically significant were determined to have drawn closer to values of the control group, and among these, the existing statistical differences for MDA level and GSH-Px activity between the trial group (Group 6) and the control group disappeared (Group 1). Compared to the pathological changes observed in the liver parenchyma, remark cords, sinusoids and hepatocytes in the group which was administered paracetamol alone (Group 4), lesions were determined to be less severe particularly in the group (Group 6) which received royal jelly for 7 days prior to paracetamol. In conclusion, the administration of royal jelly as a hepatoprotective agent for 7 days against paracetamol-induced liver damage was determined to exhibit marked protective effect on liver tissue.

连续服用蜂王浆7天可以减轻扑热息痛造成的小鼠肝损伤。

[ 本帖最后由 lemonades 于 2009-9-22 12:47 编辑 ]

作者: lemonades 时间: 2009-9-22 12:11

Evaluation of the immunomodulatory activities of royal jelly components in vitro.
Gasic S, Vucevic D, Vasilijic S, Antunovic M, Chinou I, Colic M.
Institute of Medical Research, MMA, Belgrade, Crnotravska, Belgrade, Serbia.

In this work the effect of different components isolated from royal jelly (RJ) was studied using an in vitro rat T-cell proliferation assay. We found that lower concentrations of MEL 174 (final water extract of RJ) and MEL 147 (3-10-dihydroxydecanoic acid) stimulated T-cell proliferation, triggered by concanavalin A (Con-A) and the process was followed by an increase in the production of interleukin-2 (IL-2). Higher concentrations of MEL 174, MEL 247 (dry powder of RJ) and MEL 138 (trans-10-hydroxydec-2-enoic acid) inhibited T-cell proliferation. The inhibition of T-cell proliferation in the presence of MEL 174 was followed by a decrease in IL-2 production, which was partly abrogated by exogenous IL-2, a decrease in nitric oxide (NO) production and increased apoptosis. In conclusion, our results showed the complexity of biological activity of RJ and suggest that its water extract possesses the most potent immunomodulatory activity in vitro.
1: Immunopharmacol Immunotoxicol. 2007;29(3-4):521-36

[ 本帖最后由 lemonades 于 2009-9-22 12:18 编辑 ]

作者: lemonades 时间: 2009-9-22 12:17

2楼的摘译：
从蜂王浆中分离了不同的成分，进行鼠T-细胞增长实验。低浓度的MEL174和MEL147（3-10-dihydroxydecanoic acid）刺激T-细胞增长，引发Con-A进而引发IL-2的增长。高浓度的MEL174, MEL247（蜂王浆干粉）和MEL138抑制T-细胞增长，MEL174抑制T细胞增长，引发IL-2减少，NO减少，增加凋亡。
结论，结果显示蜂王浆生物活性的复杂性，提示可能其水提取物具有最强的体外免疫调节作用。

[ 本帖最后由 lemonades 于 2009-9-22 12:24 编辑 ]

作者: lemonades 时间: 2009-9-22 12:29

蜂王浆的活性还真复杂，同样是水提取物，低浓度促进，高浓度抑制T细胞。

作者: 岩浆中的热带鱼 时间: 2009-9-22 12:33

现在蜂王浆假的多的很吧。介绍下。

作者: lemonades 时间: 2009-9-22 12:42

Functional Properties of Honey, Propolis, and Royal Jelly
M. VIUDA-MARTOS, Y. RUIZ-NAVAJAS, J. FERN´ANDEZ-L´OPEZ, AND J.A. P´EREZ-´ALVAREZ
Propolis and its derivates have the capacity to inhibit virus propagation. Several in vitro studies have shown the effect of propolis on the DNA and RNA of different viruses, among them Herpes simplex type 1, Herpes simplex type 2, adenovirus type 2, vesicular estomatitis virus, and poliovirus type 2. The effects observed involve a reduction in viral multiplication and even a virucidal action (Amoros and others 1992a).
It has also been claimed that various propolis fractions affect the replication of viruses such as vaccinia virus and the virus responsible forNewcastle disease (Maksimova and others 1985). Substances isolated from propolis have also been seen to have antiviral activity. For example, isopentyl ferulate inhibits the infectious activity of Hong Kong virus A (Serkedjieva and others 1992). In studies by Critchfield and others (1996), it was seen that characteristic honey flavonoids, like chrysin, acacetin, and apigenin, inhibit the activation of HIV-1 in latent models of infection through a mechanism that probably includes inhibition of viral transcription. Two of the flavonoids present in propolis (chrysin and campherol) have
also been studied and were seen to be very active in the inhibition of replications of several herpes viruses, adenovirus, and rotavirus (Cheng and Wong 1996), while other flavonoids, which are responsible
for antioxidant activity (galangin and acacentin) had no effect on these viruses (Debiaggi and others 1990; Amoros and others 1992b). However, other studies have pointed to the antiviral effect of galangin on herpes simple virus (HSV) and Coxsackie b virus (Meyer and others 1997). Flavonoids such as quercetin and rutin, which are found in both honey and propolis (Yao and others 2004; Orsolic and Basic 2005), show antiviral activity against HSV, syncytial virus, poliovirus, and Sindbis virus (Selway 1986;Middleton and Chithan 1993). The action mechanisms proposed for these compounds are related with the inhibition of viral polymerase and the binding of viral nucleic acid or viral capsid proteins (Selway 1986). Up to now,we have referred to the separate actions of the phenolic compounds present in honey or propolis and howthe flavonoids show antiviral activity. However, the individual components may also act synergistically. Indeed, some studies have pointed to such synergism. For example, Amor´os and others (1992b) and Cushine and Lamb (2005) mention the synergistic effect of apigenin and campherol on SV, which would explain why honey and propolis present greater antiviral activity than their individual components.

[ 本帖最后由 lemonades 于 2009-9-22 12:44 编辑 ]

作者: lemonades 时间: 2009-9-22 12:46

6楼知识点：蜂胶和蜂蜜中一些黄酮和异黄酮类成分显示出抗病毒的体外活性，这些病毒株包括HSV等等，没有HBV。蜂胶和蜂蜜联用时，抗病毒效果更好。整个抗病毒活性不涉及蜂王浆。

作者: lemonades 时间: 2009-9-22 12:46

原帖由 岩浆中的热带鱼 于 2009-9-22 12:33 发表
现在蜂王浆假的多的很吧。介绍下。

这个不是我的专长，我只负责查文献，介绍文献中的知识

作者: lemonades 时间: 2009-9-22 12:53

Propolis and the immune system: a review.Sforcin JM.
Department of Microbiology and Immunology, Biosciences Institute, UNESP, 18618-000 Botucatu, SP, Brazil. [email protected]

Propolis has been used empirically for centuries and it was always mentioned as an immunomodulatory agent. In recent years, in vitro and in vivo assays provided new information concerning its mechanisms of action, thus a review dealing with propolis and the immune system became imperative. This review compiles data from our laboratory as well as from other researchers, focusing on its chemical composition and botanical sources, the seasonal effect on its composition and biological properties, its immunomodulatory and antitumor properties, considering its effects on antibody production and on different cells of the immune system, involving the innate and adaptive immune response. In vitro and in vivo assays demonstrated the modulatory action of propolis on murine peritoneal macrophages, increasing their microbicidal activity. Its stimulant action on the lytic activity of natural killer cells against tumor cells, and on antibody production was demonstrated. Propolis inhibitory effects on lymphoproliferation may be associated to its anti-inflammatory property. In immunological assays, the best results were observed when propolis was administered over a short-term to animals. Propolis antitumor property and its anticarcinogenic and antimutagenic potential are discussed. Since humans have used propolis for different purposes and propolis-containing products have been marketed, the knowledge of its properties with scientific basis is not only of academic interest but also of those who use propolis as well. This review opens a new perspective on the investigation of propolis biological properties, mainly with respect to the immune system.

作者: lemonades 时间: 2009-9-23 00:55

查蜂王浆的文献到96年，未见任何抗病毒相关活性，有雌激素作用，降血压作用。关于其免疫调节作用，很复杂。因为其中几种主要成分，如10－HDA，等等，都有免疫调节作用，剂量的不同和用药途径的不同，都可能产生抑制或刺激两种不同的效果。

[ 本帖最后由 lemonades 于 2009-9-23 01:01 编辑 ]

作者: lemonades 时间: 2009-9-23 01:07

Propolis and Herba Epimedii extracts enhance the non-specific immune response and disease resistance of Chinese sucker, Myxocyprinus asiaticus.Zhang G, Gong S, Yu D, Yuan H.
College of Fisheries, Huazhong Agricultural University, Wuhan 430070, China.

The effect of traditional Chinese medicine (TCM) formulated from propolis and Herba Epimedii extracts at the ratio of 3:1 (w/w) on non-specific immune response of Chinese sucker (Myxocyprinus asiaticus) was investigated. Fish were fed diets containing 0 (control), 0.1%, 0.5% or 1.0% TCM extracts for five weeks. The respiratory burst and phagocytic activities of blood leukocytes, lysozyme and natural haemolytic complement activities in plasma were measured weekly. After five weeks of feeding, fish were infected with Aeromonas hydrophila and mortalities were recorded. Results of this study showed that feeding Chinese sucker with different dosage of TCM extracts stimulated respiratory burst activity, phagocytosis of phagocytic cells in blood and lysozyme activity in plasma. They had no effect on plasma natural haemolytic complement activity. All dosage of treated groups showed reduced mortality following A. hydrophila infection. Feed containing 0.5% TCM extracts was the most effective with the mortality of the fish significantly reduced by 35% compared to the control. The results indicate that propolis and Herba Epimedii extracts in combination enhances the non-specific immune response and disease resistance of Chinese sucker against A. hydrophila.

作者: lemonades 时间: 2009-9-23 01:11

11楼意译：
将蜂胶和淫羊藿提取物以体积比3：1混合后加上饲料喂一种鱼，发现混入0.5％的以上混合物的饲料对鱼的生存率最有效果，减少了35％的死亡率。说明这种提取物可能增强了非特异免疫反应。

作者: 高峡神女 时间: 2009-9-23 08:11

看到了绽放的红玫瑰，也看到了对未来的希望！

作者: deng245 时间: 2009-9-23 09:19

楼主、有没有介绍蜂花粉方面的

作者: lemonades 时间: 2009-9-23 09:40

原帖由 deng245 于 2009-9-23 09:19 发表
楼主、有没有介绍蜂花粉方面的

先完成蜂胶，蜂蜜后再考虑蜂花粉，不好意思，我想按顺序来，不然太乱了。

作者: mtv982 时间: 2009-9-24 10:29

等待下文.
另外帮忙查一下:已知蜂王浆中的激素不适合儿童和有乳腺增生的成年人,那么松花粉中的植物激素对人体有害么?

作者: deng245 时间: 2009-9-24 10:30

原帖由 lemonades 于 2009-9-23 09:40 发表

先完成蜂胶，蜂蜜后再考虑蜂花粉，不好意思，我想按顺序来，不然太乱了。

嗯、俺等

作者: mtv982 时间: 2009-9-24 17:33

男性长期吃花粉比如松花粉会不会乳腺增生?

作者: GK 时间: 2009-9-24 20:40

我在国内吃过一关时间蜂王浆，没什么太大效果。可能那时候心态太急，没有细水长流。

现在每天早上起来喝蜂蜜水，感觉不错。

美国那里有卖蜂王浆阿？

作者: lemonades 时间: 2009-9-24 23:46

原帖由 GK 于 2009-9-24 20:40 发表
我在国内吃过一关时间蜂王浆，没什么太大效果。可能那时候心态太急，没有细水长流。

现在每天早上起来喝蜂蜜水，感觉不错。

美国那里有卖蜂王浆阿？ ...

costco有蜂王浆和蜂蜡的胶囊，你搜索，很多卖的，新鲜的，干粉，胶囊都有

作者: mtv982 时间: 2009-9-25 06:43

http://news.sohu.com/20060629/n243996623.shtml

作者: mtv982 时间: 2009-9-25 07:41

蜂王浆和花粉都是非常好的东西,天然,但对于乳腺增生的人来说因含激素建议少量吃或不吃,非要吃的话加吃含碘丰富的海带(可降低增生).
蜂胶和蜂蜜不含或很少激素,但蜂蜜含大量的果糖和葡陶糖,所以肥胖的人和有糖尿病的人宜少吃.
现在看来,只有蜂胶是适合绝大多数人吃的,但也还是有千分之三的人吃了早期会过敏.

[ 本帖最后由 mtv982 于 2009-9-25 08:00 编辑 ]

作者: mtv982 时间: 2009-9-25 08:13

对于不宜吃蜂王浆花粉和蜂蜜的乙肝人,可以试试螺旋藻.http://baike.baidu.com/view/4726.htm经国内外大量科研试验证明，螺旋藻在降低胆固醇和血脂，抗癌，减肥，养胃护胃，治疗贫血及微量元素缺乏，护肝，增进免疫，调整代谢机能等方面都有积极作用，被联合国粮农组织和联合国世界食品协会推荐为“二十一世纪最理想的食品”。

黄金组合:蜂胶和螺旋藻.

作者: mtv982 时间: 2009-9-25 12:24

对于松花粉和乳腺增生之间的关系,我搜索了一下网上的资料,发现有的医生说可以吃,有的医生说不能吃.再来看一下:松花粉对内分泌的影响以及乳腺增生的病因-内分泌失调.

专家指出乳腺增生不是一个独立的病，它的主因是内分泌失调，可由多个内分泌器官疾病而引发，如脑垂体、甲状腺紊乱等。在内分泌失调的情况下，女性体内雌激素水平升高，雌、孕激素水平不平衡，出现乳腺组织增生过度，经过一段时间后，增生的乳腺组织不能完全消退，便形成真正意义上的乳腺增生。
　　因此，治疗乳腺增生最根本的方法也是调节内分泌，通过调整内分泌，从而改善增生病症。所以，专家指出患者知道自己发生了乳腺增生，首先要做一个内分泌的检查，也就是所说的性激素指标检查，查出导致乳腺增生的具体原因，这样治疗才能既针对病症，又能调整内分泌。从调整内分泌入手，乳腺疾病的治疗会更彻底。

松花粉含有丰富的功能性物质（包括蛋白质、维生素、微量元素、黄酮类化合物等），这些物质协调作用于机体，调节机体的多种平衡，平衡体内营养，加强新陈代谢，防止毛细血管通透性障碍。松花粉还能促进内分泌腺的发育，有提高和调剂内分泌腺分泌功能，因此对由内分泌功能紊乱引起的疾病起到治疗作用。

作者: mtv982 时间: 2009-9-25 12:53

蜂王浆能促进内分泌系统功能正常,但蜂王浆含有雌激素,可能会诱发人体乳腺增生.而乳腺增生不是一个独立的病，它的主因是内分泌失调.
非常的矛盾!

作者: mtv982 时间: 2009-9-26 11:26

http://www.hbvhbv.com/forum/view ... &extra=page%3D1
对花粉中雌二醇和睾酮含量研究表明，不同花粉品种其含量不同，差别甚大。油松花粉的睾酮含量27.37±3.41ng/g，白皮松花粉较低，为11.00±1.06ng/g,睾酮含量代表雄激素含量.这两种松花粉雄激素含量较低.男女老少除婴幼儿和过敏者外都适宜,马尾松花粉的数值没有找到,估计和前两种松花粉的雄激素含量差别不大.结论:松花粉不会诱发乳腺增生,但对于雌激素含量高的个别蜂花粉慎用.
而蜂王浆含有动物雌激素,虽然能调节人体的内分泌系统,但对于有乳腺增生的乙肝患者个人建议少量用或不用.

[ 本帖最后由 mtv982 于 2009-9-26 12:08 编辑 ]

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