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标题: 在未经治疗的慢性乙型肝炎病毒感染中清除乙型肝炎 e 抗原 [打印本页]

作者: StephenW    时间: 2022-11-15 16:58     标题: 在未经治疗的慢性乙型肝炎病毒感染中清除乙型肝炎 e 抗原

在未经治疗的慢性乙型肝炎病毒感染中清除乙型肝炎 e 抗原:系统评价和荟萃分析
Amir M Mohareb、Anne F Liu、Arthur Y Kim、Patrick A Coffie、Menan Gérard Kouamé、Kenneth A Freedberg、Anders Boyd、Emily P Hyle
传染病杂志,第 226 卷,第 10 期,2022 年 11 月 15 日,第 1761-1770 页,https://doi.org/10.1093/infdis/jiac168
发表:
2022 年 5 月 2 日
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抽象的
背景

在乙型肝炎病毒 (HBV) 感染者中,乙型肝炎 e 抗原 (HBeAg) 的持续存在与临床进展和治疗需求相关。 HBeAg 消失代表部分免疫控制,是慢性 HBV 自然病程中的关键事件。
方法

我们对报告未经治疗的慢性 HBV 患者 HBeAg 消失的队列研究进行了系统回顾和荟萃分析。我们使用随机效应模型评估了 HBeAg 丢失,并对区域进行了子分析。
结果

我们筛选了 10 560 篇出版物,进行了 196 次全文分析,并纳入了 26 项研究进行荟萃分析。 HBeAg 消失的汇总率为 6.46/100 人年 (PY)(95% 置信区间,5.17-8.08)。元回归显示,欧洲参与者和研究的年龄越大,HBeAg 消失率越高。每 100 个 PY 的发生率为 7.43(95% 置信区间,6.30-8.75;1 项研究),东地中海为 3.24(2.61-4.02;1 项研究),欧洲为 13.67(11.21-16.66;4 项研究),7.34( 4.61–11.70;5 项研究)在北美,5.53(4.05–7.55;15 项研究)在西太平洋。
结论

自发性 HBeAg 丢失的发生率为 6.46/100 PYs。地区和年龄组的差异可能反映了流行病学、免疫学或 HBV 基因型相关的差异。
慢性乙型肝炎感染,乙型肝炎e抗原,乙型肝炎e抗原清除,自然史
作者: StephenW    时间: 2022-11-15 16:58

Clearance of Hepatitis B e Antigen in Untreated Chronic Hepatitis B Virus Infection: A Systematic Review and Meta-analysis
Amir M Mohareb, Anne F Liu, Arthur Y Kim, Patrick A Coffie, Menan Gérard Kouamé, Kenneth A Freedberg, Anders Boyd, Emily P Hyle
The Journal of Infectious Diseases, Volume 226, Issue 10, 15 November 2022, Pages 1761–1770, https://doi.org/10.1093/infdis/jiac168
Published:
02 May 2022
Article history

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Abstract
Background

In people with hepatitis B virus (HBV) infection, persistence of hepatitis B e antigen (HBeAg) is associated with clinical progression and need for treatment. HBeAg loss represents partial immune control and is a critical event in the natural history of chronic HBV.
Methods

We conducted a systematic review and meta-analysis of cohort studies that report HBeAg loss among people with untreated chronic HBV. We evaluated HBeAg loss using a random-effects model and conducted subanalysis on region.
Results

We screened 10 560 publications, performed 196 full-text analyses, and included 26 studies for meta-analysis. The pooled rate of HBeAg loss was 6.46/100 person-years (PYs) (95% confidence interval, 5.17–8.08). Meta-regression showed that older age of participants and studies in Europe were associated with higher rate of HBeAg loss. Rates per 100 PYs were 7.43 (95% confidence interval, 6.30–8.75; 1 study) in Africa, 3.24 (2.61­–4.02; 1 study) in the Eastern Mediterranean, 13.67 (11.21–16.66; 4 studies) in Europe, 7.34 (4.61­–11.70; 5 studies) in North America, and 5.53 (4.05­–7.55; 15 studies) in the Western Pacific.
Conclusions

Spontaneous HBeAg loss occurs at a rate of 6.46/100 PYs. Variations by region and age group may reflect epidemiological, immunological, or HBV genotype-related differences.
chronic hepatitis B infection, hepatitis B e antigen, hepatitis B e antigen clearance, natural history





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