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标题: 肝細胞癌患者的乙型肝炎及其與甲胎蛋白和肝酶的相關性 [打印本页]

作者: StephenW 时间: 2022-9-24 14:00 标题: 肝細胞癌患者的乙型肝炎及其與甲胎蛋白和肝酶的相關性

肝細胞癌患者的乙型肝炎及其與甲胎蛋白和肝酶的相關性
Richa Surit 1，Ravi Shekhar 1，Dinesh Kumar Sinha 2，Sanjeet Kumar Singh 3，Uday Kumar 1，Nidhi Prasad 4
隸屬關係
隸屬關係

1
印度比哈爾邦巴特那英迪拉甘地醫學研究所生物化學系。
2
印度比哈爾邦巴特那英迪拉甘地醫學科學研究所放射腫瘤學系。
3
病理學系，英迪拉甘地醫學科學研究所，巴特那，比哈爾邦，印度。
4
印度比哈爾邦巴特那英迪拉甘地醫學科學研究所微生物學系。

PMID：36149138 DOI：10.4103/jcrt.JCRT_239_19

抽象的

背景：印度每年每 100,000 人中，男性肝細胞癌 (HCC) 發生率為 0.7 至 7.5，女性為 0.2 至 2.2。發生 HCC 的主要危險因素是乙型肝炎病毒 (HBV)、丙型肝炎病毒和肝硬化的感染。臨床醫生廣泛使用甲胎蛋白 (AFP) 和肝酶來診斷 HCC。

目的和目的：本研究在與 HBV 感染相關的 HCC 患者中進行，並評估 AFP 和肝酶在其中的意義。

材料與方法：採集68例患者的血液樣本。分析樣品的 AFP 和肝酶（丙氨酸氨基轉移酶 [ALT]、天冬氨酸氨基轉移酶 [AST] 和鹼性磷酸酶 [ALP]）。通過自動分析儀 OLYMPUS AU400 評估肝酶。通過化學發光免疫測定法分析 AFP。

結果：血清乙型肝炎表面抗原（HBsAg）陰性和陽性患者的 AFP 平均值為 22745.4 至 23269.3 ng/ml，P = 0.921。 HbsAg 陰性患者的 ALP 平均值為 418 U/ml，而陽性患者為 310 U/ml。兩組均未顯示 AFP 水平有任何顯著變化。 ALP在陰性組中略有上升。其他參數並未在所有患者中顯示出顯著上升。

結論：這些值表明病毒病因對 HCC 患者的 AFP 和肝酶水平沒有顯著影響。

關鍵詞：甲胎蛋白；肝細胞癌;肝酶;血清乙型肝炎表面抗原。
利益衝突聲明

沒有任何

作者: StephenW 时间: 2022-9-24 14:01

Hepatitis B in hepatocellular carcinoma patients and its correlation with alpha-fetoprotein and liver enzymes
Richa Surit 1 , Ravi Shekhar 1 , Dinesh Kumar Sinha 2 , Sanjeet Kumar Singh 3 , Uday Kumar 1 , Nidhi Prasad 4
Affiliations
Affiliations

1
Department of Biochemistry, Indira Gandhi Institute of Medical Sciences, Patna, Bihar, India.
2
Department of Radiation Oncology, Indira Gandhi Institute of Medical Sciences, Patna, Bihar, India.
3
Department of Pathology, Indira Gandhi Institute of Medical Sciences, Patna, Bihar, India.
4
Department of Microbiology, Indira Gandhi Institute of Medical Sciences, Patna, Bihar, India.

PMID: 36149138 DOI: 10.4103/jcrt.JCRT_239_19

Abstract

Background: Hepatocellular carcinoma (HCC) in India ranges from 0.7 to 7.5 for men and 0.2 to 2.2 for women, per 100,000 population per year. The major risk factors for the development of HCC are infection with hepatitis B virus (HBV), hepatitis C virus, and cirrhosis of liver. Alpha-fetoprotein (AFP) and liver enzymes are widely used by clinicians for diagnostic purpose in HCC.

Aims and objective: This study was conducted in HCC patients related to HBV infection and to assess the significance of AFP and liver enzymes in it.

Materials and methods: Blood samples of 68 patients were taken. The samples were analyzed for AFP and liver enzymes (alanine aminotransferase [ALT], aspartate aminotransferase [AST], and alkaline phosphatase [ALP]). Liver enzymes were estimated by auto analyzer OLYMPUS AU400. AFP was analyzed by chemiluminescence immunoassay.

Results: The mean values of AFP in serum hepatitis B surface antigen (HBsAg) negative and positive patients ranges from 22745.4 to 23269.3 ng/ml with P = 0.921. The mean value of ALP in HbsAg-negative patients was 418 U/ml, whereas in positive patients, it was 310 U/ml. Both the groups did not show any significant changes in AFP levels. The ALP showed slight rise in negative group. The other parameters did not show significant rise in all patients.

Conclusion: These values suggest that there was no significant influence of viral etiology on AFP and liver enzymes level in HCC patients.

Keywords: Alpha-fetoprotein; hepatocellular carcinoma; liver enzymes; serum hepatitis B surface antigen.
Conflict of interest statement

None

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