中国HBV相关肝病患者人口统计学和临床​​特征的性别差异

StephenW

中国HBV相关肝病患者人口统计学和临床​​特征的性别差异
刘美 #1 , 陆丽 # 2 , 景照 1 , Gabor S Ungvari 3 4 , Chee H Ng 5 , 段中平 1 , Su-Jun Zheng 1 , Yu-Tao Xiang 6 7 8
隶属关系
隶属关系

    1
    【作者单位】： 首都医科大学北京佑安医院人工肝中心;
    2
    【作者单位】： 广州医科大学附属脑科医院(广州惠爱医院);
    3
    澳大利亚圣母大学，弗里曼特尔，澳大利亚。
    4
    澳大利亚珀斯西澳大利亚大学/格雷兰兹医院医学院精神病学系。
    5
    澳大利亚维多利亚州里士满墨尔本大学墨尔本诊所和圣文森特医院精神病学系。
    6
    中国澳门特别行政区澳门大学认知与脑科学中心。
    7
    澳门大学人文社会科学高等研究院，中国澳门特别行政区。
    8
    中国澳门特别行政区澳门大学健康科学学院公共卫生与药物行政学系及转化医学研究所精神科。

#
同等贡献。

    PMID：35959480 PMCID：PMC9359133 DOI：10.7717/peerj.13828

抽象的

背景：研究了乙型肝炎病毒 (HBV) 相关肝病患者在人口统计学和临床​​特征方面的性别差异。

方法：总体而言，连续纳入 634 名患者（44.7 ± 13.8 岁）。在评估访谈期间收集人口统计学和临床​​特征数据。男性和女性患者在人口统计学和临床​​数据方面的比较使用单变量分析进行。使用逻辑回归或适当的协方差分析检查人口统计学和临床​​变量与性别之间的独立关联。

结果：研究样本包括 452 名男性和 182 名女性患者。多元逻辑回归分析显示，在职（OR = 3.4）、个人月收入<3000元（OR = 0.3）、正在饮酒（OR = 6.4）、肝硬化（OR = 5.9）、肝细胞癌（HCC）（OR = 8.5）和较轻的失眠症（OR = 0.6）与男性独立相关。协方差分析显示，在控制其他潜在混杂变量后，HBV 相关疾病的晚发（F = 4.5，p = 0.03）和年龄较大（F = 6.7，p = 0.009）与男性独立相关。

结论：鉴于男性和女性 HBV 相关肝病患者的临床差异显着，应更加关注该人群的性别特异性治疗和预防。

关键词：人口统计；性别差异； HBV相关的肝脏疾病。

©2022 刘等人。

StephenW

Gender differences in demographic and clinical characteristics in patients with HBV-related liver diseases in China
Mei Liu #  1 , Lu Li #  2 , Jing Zhao  1 , Gabor S Ungvari  3   4 , Chee H Ng  5 , Zhongping Duan  1 , Su-Jun Zheng  1 , Yu-Tao Xiang  6   7   8
Affiliations
Affiliations

    1
    Artificial Liver Center, Beijing YouAn Hospital, Capital Medical University, Beijing, China.
    2
    The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital), Guangzhou, China.
    3
    University of Notre Dame Australia, Fremantle, Australia.
    4
    Division of Psychiatry, School of Medicine, University of Western Australia/Graylands Hospital, Perth, Australia.
    5
    Department of Psychiatry, The Melbourne Clinic and St Vincent's Hospital, University of Melbourne, Richmond, Victoria, Australia.
    6
    Centre for Cognitive and Brain Sciences, University of Macau, Macao SAR, China.
    7
    Institute of Advanced Studies in Humanities and Social Sciences, University of Macau, Macao SAR, China.
    8
    Unit of Psychiatry, Department of Public Health and Medicinal Administration, & Institute of Translational Medicine, Faculty of Health Sciences, University of Macau, Macao SAR, China.

#
Contributed equally.

    PMID: 35959480 PMCID: PMC9359133 DOI: 10.7717/peerj.13828

Abstract

Background: The gender differences in demographic and clinical characteristics were examined in patients with hepatitis B virus (HBV)-related liver diseases.

Methods: Overall, 634 patients (44.7 ± 13.8 years) were consecutively included. Data of demographic and clinical characteristics were collected during an assessment interview. Comparisons between male and female patients in terms of demographic and clinical data were carried out using univariate analyses. The independent associations between the demographic and clinical variables and gender were examined with either logistic regression or analysis of covariance as appropriate.

Results: The study sample consisted of 452 male and 182 female patients. Multiple logistic regression analyses revealed that being employed (OR = 3.4), personal monthly income <3,000 yuan (OR = 0.3), being current alcohol users (OR = 6.4), Cirrhosis (OR = 5.9), Hepatocellular Carcinoma (HCC) (OR = 8.5) and having less severe insomnia (OR = 0.6) were independently associated with male gender. The analysis of covariance revealed that after controlling for other potential confounding variables, later onset of HBV-related diseases (F = 4.5, p = 0.03) and older age (F = 6.7, p = 0.009) were independently associated with male gender.

Conclusions: Given the significant clinical differences in male and female patients with HBV-related liver diseases, more attention should be given to gender-specific treatment and prevention for this population.

Keywords: Demographic; Gender difference; HBV-related liver diseases.

©2022 Liu et al.

StephenW

https://doi.org/10.7717/peerj.13828