关于组装生物科学
Assembly Bio 是一家临床阶段的生物技术公司，致力于为全球 2.96 亿乙型肝炎病毒 (HBV) 感染者提供有限的治愈性疗法。作为开发新型强效口服研究性核心抑制剂的先驱，Assembly Bio 的方法旨在打破 HBV 复杂的病毒复制周期，使患者免于终生治疗。 Assembly Bio 的战略包括更有效的下一代核心抑制剂候选药物的领先组合、HBV 治愈的概念验证组合研究以及专注于发现针对 HBV 和其他病毒性疾病的其他新型抗病毒机制的研究计划。欲了解更多信息，请访问 assemblybio.com。作者: StephenW 时间: 2022-6-15 20:35
Assembly Biosciences to Highlight Data from HBV Core Inhibitor Programs at EASL’s International Liver Congress™ 2022
June 8, 2022
SOUTH SAN FRANCISCO, Calif., June 08, 2022 (GLOBE NEWSWIRE) -- Assembly Biosciences, Inc. (Nasdaq: ASMB), a clinical-stage biotechnology company developing innovative, investigational therapeutics targeting hepatitis B virus (HBV) and other viral diseases, today announced that six abstracts have been accepted for presentation at the International Liver Congress™, the Annual Meeting of the European Association for the Study of the Liver (EASL) taking place virtually and in London on June 22-26, 2022. During the meeting, data from Assembly Bio’s investigational core inhibitor programs, vebicorvir (VBR), ABI-H3733 (3733) and ABI-4334 (4334), will be featured in six poster presentations.
“The data from our core inhibitor candidates being presented at EASL’s International Liver Congress demonstrate the compelling scientific rationale and recent progress for our pipeline of next-generation core inhibitors, 3733 and 4334, and provide further characterization of VBR, which is being evaluated in ongoing Phase 2 triple combination studies. We are pleased that such a breadth of data from our nonclinical and clinical development efforts have been accepted for presentation, and we look forward to providing these data that further demonstrate the strength of our pipeline focused on providing finite and curative therapies for HBV,” said John McHutchison, AO, MD, chief executive officer and president of Assembly Bio.
Presentation Details
Posters are expected to be made available to conference registrants through the online EASL portal at the start of the meeting on the morning of Wednesday, June 22, 2022. The posters will be available subsequently on the “Events & Presentations” page in the “Investors” section of Assembly Bio's website at www.assemblybio.com
Next-Generation Core Inhibitors:
Poster SAT-383: ABI-4334, a novel inhibitor of hepatitis B virus core protein, promotes formation of empty capsids and prevents cccDNA formation by disruption of incoming capsids
Session: Viral hepatitis B/D: therapy
Date and Time: June 25 at 9:00 AM BST
Presenter: Kathryn M. Kitrinos, PhD, Assembly Bio
Poster SAT-389: Improving the pharmacokinetic profile of the hepatitis B virus core inhibitor ABI-H3733 following oral administration: results from new formulation activities
Session: Viral hepatitis B/D: therapy
Date and Time: June 25 at 9:00 AM BST
Presenter: Michael Shen, PhD, Assembly Bio
Vebicorvir:
Poster THU-346: Greater sequence diversity during early hepatitis B virus decline on vebicorvir plus entecavir is associated with a lower level of virus rebound following switch to entecavir monotherapy
Session: Viral Hepatitis A, B, C, D, E: virology
Date: June 23 9:00 AM BST
Presenter: Kathryn M. Kitrinos, PhD, Assembly Bio
Poster SAT-363: Evaluation of the disposition and mass balance recovery of vebicorvir, a first-generation hepatitis B core inhibitor, in rats and humans
Session: Viral hepatitis B/D: therapy
Date and Time: June 25 at 9:00 AM BST
Presenter: Katie Zomorodi, PhD, Assembly Bio
Poster SAT-366: Deeper virologic suppression with the addition of vebicorvir, a first-generation hepatitis B core inhibitor, to entecavir correlates with reduced inflammation and fibrosis-4 index in treatment-naïve patients with HBeAg positive chronic hepatitis B
Session: Viral hepatitis B/D: therapy
Date and Time: June 25 at 9:00 AM BST
Presenter: Mark S. Sulkowski, MD, Johns Hopkins University
Poster SAT-388: Evaluation of the drug-drug interaction profile of vebicorvir, a first-generation hepatitis B core inhibitor: findings from Phase 1 and Phase 2a studies
Session: Viral hepatitis B/D: therapy
Date and Time: June 25 at 9:00 AM BST
Presenter: Katie Zomorodi, PhD, Assembly Bio
About Assembly Biosciences
Assembly Bio is a clinical-stage biotechnology company committed to bringing finite and curative therapies to the 296 million people living with hepatitis B virus (HBV) worldwide. A pioneer in the development of a new class of potent, oral investigational core inhibitors, Assembly Bio’s approach aims to break the complex viral replication cycle of HBV to free patients from a lifetime of therapy. Assembly Bio’s strategy includes a leading portfolio of more potent, next-generation core inhibitor drug candidates, proof-of-concept combination studies for HBV cure and research programs focused on the discovery of additional novel antiviral mechanisms for HBV and other viral diseases. For more information, visit assemblybio.com.作者: 乙肝人1949 时间: 2022-6-15 23:19