结论：在农村居住的中国老年人中，中度至重度 NAFLD 与痴呆和 AD 相关，尤其是与 VaD 相关，其中与 VaD 的关联部分由血清炎性细胞因子介导。
关键词：痴呆；炎;非酒精性脂肪肝病（NAFLD）；基于人群的研究；血清细胞因子。
本文受版权保护。版权所有。作者: StephenW 时间: 2022-5-25 19:06
Non-alcoholic fatty liver disease, serum cytokines, and dementia among rural-dwelling older adults in China: a population-based study
Yongxiang Wang 1 2 3 , Yuanjing Li 4 , Keke Liu 1 2 3 , Xiaolei Han 2 3 , Yi Dong 2 3 , Xiaojie Wang 2 3 , Mingqi Wang 2 3 , Lin Cong 1 2 3 , Qinghua Zhang 1 2 3 , Shi Tang 1 2 3 , Tingting Hou 1 2 3 , Cuicui Liu 1 2 3 , Lin Song 1 2 3 , Xiaojuan Han 1 2 3 , Davide L Vetrano 4 , Yifeng Du 1 2 3 , Chengxuan Qiu 2 4
Affiliations
Affiliations
1
Department of Neurology, Shandong Provincial Hospital affiliated to Shandong First Medical University, Jinan, Shandong, P.R. China.
2
Department of Neurology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong, P.R. China.
3
Shandong Provincial Clinical Research Center for Neurological Diseases, Jinan, Shandong, P.R. China.
4
Aging Research Center, Department of NVS, Karolinska Institutet and Stockholm University, Stockholm, Sweden.
PMID: 35608965 DOI: 10.1111/ene.15416
Abstract
Background: Little is known about whether non-alcoholic fatty liver disease (NAFLD) is associated with dementia as well as the role of serum pro-inflammatory cytokines in the association. We aimed to investigate the interrelationships of NAFLD, serum cytokines, and dementias among rural-dwelling older adults.
Methods: This population-based cross-sectional study included 5,129 participants (age ≥60 years; 61.79% women) who were living in rural communities and examined in March-September 2018. NAFLD was defined through transabdominal ultrasound examination in the absence of hepatitis B or excessive alcohol consumption. Serum cytokines were measured in a subsample (n=1,686). Dementia, Alzheimer's disease (AD), and vascular dementia (VaD) were diagnosed following international criteria. Data were analyzed with logistic regression and mediation models.
Results: Of the 5,129 participants, 455 (8.87%) were detected with moderate-to-severe NAFLD and 292 (5.69%) were diagnosed with dementia (188 with AD and 96 with VaD). The multivariable-adjusted odds ratios (ORs) associated with moderate-to-severe (vs. no-to-mild) NAFLD were 2.22 (95% confidence interval, 1.41-3.49) for all-cause dementia, 1.88 (1.01-3.50) for AD, and 2.62 (1.33-5.17) for VaD. In the cytokine subsample, controlling for multiple potential confounders, moderate-to-severe NAFLD was significantly associated with higher levels of serum monocyte chemotactic protein-1 (MCP-1), interleukin-17A (IL-17A), interleukin-6 (IL-6), interleukin-8 (IL-8), and tumor necrosis factor-α (TNF-α) (P<0.05). The mediation analysis showed that IL-6 mediated 12.56% of the association between NAFLD and VaD.
Conclusions: Moderate-to-severe NAFLD is associated with dementia and AD, especially with VaD, among rural-dwelling Chinese older adults, in which the association with VaD is partly mediated by serum inflammatory cytokines.