Trends in Prevalence and Characteristics of Resolved and Current Hepatitis B among US-Born Persons: National Health and Nutrition Examination Survey, 2001-2018
Kathleen N Ly, MPH, Jian Xing, PhD, Philip R Spradling, MD
The Journal of Infectious Diseases, jiab224, https://doi.org/10.1093/infdis/jiab224
Published:
27 April 2021
Article history
After decades of decline, US incidence of acute hepatitis B flattened since 2010. In persons aged ≥40 years and in jurisdictions affected by the opioid epidemic, there is an increase in new cases. Data suggest new infections are occurring among US-born persons.
Methods
We used National Health and Nutrition Examination Survey data during 2001-2018 to examine trends and differences in total antibody to hepatitis B virus core antigen (anti-HBc) prevalence in US-born persons. During 2013-2018, the distribution of characteristics was examined. Cochran-Mantel-Haenszel test was used to assess trends.
Results
During 2001-2006, 2007-2012, and 2013-2018, anti-HBc prevalence was 3.5%, 2.5%, and 2.6% among US-born persons, respectively. This corresponded to 5.7 (range, 4.8-6.6) million US-born persons with resolved or current HBV infection during 2013-2018, including 347,100 persons aged 6-29 years. The most pronounced increase and highest anti-HBc prevalence was among persons who reported injection drug use (IDU), which increased from 35.3% during 2001-2006 to 58.4% during 2013-2018 (P=.07).
Conclusions
Anti-HBc prevalence among US-born persons remained flat during the most recent period, coinciding with a doubling of prevalence among persons reporting IDU. These data are consistent with acute hepatitis B surveillance trends, showing increasing incidence in sub-populations where prevention could be strengthened.作者: StephenW 时间: 2021-5-1 15:20
美国出生的人中乙型肝炎和现存乙型肝炎的流行趋势和特征趋势：国家健康和营养检查调查，2001-2018年
Kathleen N Ly，MPH，Jian Xing，PhD，Philip R Spradling，MD
传染病杂志，jiab224，https://doi.org/10.1093/infdis/jiab224
发布时间：
2021年4月27日
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