Usefulness of New Shear Wave Elastography Technique for Noninvasive Assessment of Liver Fibrosis in Patients with Chronic Hepatitis B: A Prospective Multicenter Study
Jinfen Wang # 1 , Manli Wu # 1 , Runze Linghu # 2 , Jiandong Chang 3 , Min Wu 4 , Cheng Feng 5 , Xinping Ren 6 , Changzhu Liu 7 , Jie Lin 8 , Tao Song 9 , Jionghui Gu 10 , Yao Zhang 11 , Ye Fang 12 , Sumei Ma 13 , Pingxiang Hu 14 , Linsong Wu 15 , Xue Han 16 , Kaixuan Chen 17 , Qiusheng Shi 18 , Ruifang Zhang 19 , Qi Zhou 20 , Ruiqing Du 21 , Yongyan Gao 22 , Xiang Jing 23 , Shunshi Yang 24 , Chang Zhou 25 , Jian Zheng 26 , Ping Liang 2 , Rong-Qin Zheng 1
Affiliations
PMID: 33910257 DOI: 10.1055/a-1376-6734
Abstract in English, German
Purpose: To explore the usefulness of liver stiffness measurements (LSMs) by sound touch elastography (STE) and sound touch quantification (STQ) in chronic hepatitis B (CHB) patients for staging fibrosis.
Methods: This prospective multicenter study recruited normal volunteers and CHB patients between May 2018 and October 2019. The volunteers underwent LSM by STE and supersonic shear imaging (SSI) or by STQ and acoustic radiation force impulse imaging (ARFI). CHB patients underwent liver biopsy and LSM by both STE/STQ. The areas under the receiver operating characteristic curves (AUCs) for staging fibrosis were calculated.
Results: Overall, 97 volunteers and 524 CHB patients were finally eligible for the study. The successful STE and STQ measurement rates were both 100 % in volunteers and 99.4 % in CHB patients. The intraclass correlation coefficients (ICCs) for the intra-observer stability of STE and STQ (0.94; 0.90) were similar to those of SSI and ARFI (0.95; 0.87), respectively. STE and STQ showed better accuracy than the aspartate aminotransferase-to-platelet ratio index (APRI) and fibrosis-4 index (FIB-4) (AUC: 0.87 vs 0.86 vs 0.73 vs 0.77) in staging cirrhosis. However, both STE and STQ were not superior to APRI and FIB-4 in staging significant fibrosis (AUC: 0.76 vs 0.73 vs 0.70 vs 0.71, all P-values > 0.05).
Conclusion: STE and STQ are convenient techniques with a reliable LSM value. They have a similar diagnostic performance and are superior to serum biomarkers in staging cirrhosis in CHB patients.
Thieme. All rights reserved. 作者: StephenW 时间: 2021-4-29 19:47
结果：总共有97名志愿者和524名CHB患者最终符合研究条件。成功的STE和STQ测量率在志愿者中均为100％，在CHB患者中为99.4％。 STE和STQ的观察者内部稳定性的类内相关系数（ICC）（0.94; 0.90）分别类似于SSI和ARFI（0.95; 0.87）。在分期性肝硬化中，STE和STQ的准确性优于天冬氨酸氨基转移酶与血小板的比率指数（APRI）和纤维化4指数（FIB-4）（AUC：0.87 vs 0.86 vs 0.73 vs 0.77）。然而，在分期显着纤维化方面，STE和STQ均不优于APRI和FIB-4（AUC：0.76 vs 0.73 vs 0.70 vs 0.71，所有P值均大于0.05）。