Predictive value of noninvasive indices in chronic hepatitis B virus-related fibrosis
Öznur, Meltema; Topçu, Birolb; Çelikkol, AliyecAuthor Information
aMedical Pathology Department, Tekirdağ Namik Kemal University Faculty of Medicine
bBiostatistics Department, Tekirdağ Namik Kemal University Faculty of Medicine
cMedical Biochemistry Department, Tekirdağ Namik Kemal University Faculty of Medicine,Tekirdağ, Turkey
Received 5 June 2020 Accepted 21 July 2020
Correspondence to Meltem Öznur, MD, Medical Pathology Department, Tekirdağ Namik Kemal University, Namik Kemal, Kampüs Street, No:1, 59030, Süleymanpaşa,Tekirdag,Turkey, Tel: +90 282 250 7439; fax: +90 282 250 99 50; e-mail: [email protected]
European Journal of Gastroenterology & Hepatology: April 2021 - Volume 33 - Issue 4 - p 577-582
doi: 10.1097/MEG.0000000000002045
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Abstract
Objectives
Despite being an invasive method, liver biopsy followed by pathological grading remains the gold standard in evaluating liver fibrosis resulting from chronic hepatitis B virus (HBV) infection. The present study aims to evaluate the utility of biochemical parameters and their derived indices in predicting development of fibrosis related to HBV infection.
Patients and methods
Pathology results and biochemical parameters of patients who underwent liver biopsy were retrieved from electronic archive records dated 2010–2019 and evaluated retrospectively. Pathological fibrosis grading was performed as per Ishak scoring, with scores of 1–2 considered as mild fibrosis and 3–6 as advanced fibrosis.
Results
The mean age of 302 patients was 37.69 ± 11.33 years. Of the 302 patients, 230 (76.2%) had mild fibrosis and 72 (23.8%) had advanced fibrosis. Age-platelet index, aspartate aminotransferase/platelet ratio index, fibrosis-4 (FIB-4), modified fibrosis-4, platelets count, aspartate aminotransferase to alanine aminotransferase ratio/platelet ratio index, Goteborg University Cirrhosis Index and King’s score were markedly and significantly higher in patients with advanced fibrosis than those with mild fibrosis. FIB-4, age-platelet index and King’s score had higher (>80%) area under the curve values than other indices in the receiver operating characteristics analysis. Evaluation of sensitivity, specificity and accuracy of these indices with the specified cut-off values revealed 87% sensitivity with FIB-4, 70% specificity with King’s score and 72% accuracy with the age-platelet index.
Conclusion