Distribution and factors associated with serum HBV pregenomic RNA levels in Chinese chronic hepatitis B patients
Meng-Lan Wang 1 , Juan Liao 1 , Feng Ye 2 , Ya-Chao Tao 1 , Dong-Bo Wu 1 , Min He 1 , Hong Tang 1 , En-Qiang Chen 1
Affiliations
Affiliations
1
Center of Infectious Diseases, West China Hospital of Sichuan University, Chengdu, 610041, China.
2
Beijing GenomePrecision Technology CO., LTD., Beijing, 100176, China.
PMID: 32949174 DOI: 10.1002/jmv.26529
Abstract
Background: Correlations between serum HBV pgRNA, HBsAg and HBcrAg levels, and influencing factors of serum HBV pgRNA levels in Chinese CHB patients are rarely reported.
Methods: This was a retrospective cohort study consisting of 204 outpatients with CHB. Serum levels of HBV pgRNA, HBsAg and HBcrAg were quantitative measured in frozen blood samples. The linear regression and multivariate logistic regression analysis were performed to determine associated factors of serum HBV pgRNA levels.
Results: In this cohort, the median serum HBV pgRNA level was 4.12 log10 copies/mL and 33.33%(68/204) of them had serum HBV pgRNA under low limit of detection(LLD) (<500 copies/mL); and the percentage of patients with serum HBV pgRNA under LLD in HBeAg-positive patients was significantly lower than that in HBeAg-negative patients (15.75%[23/46] vs.77.59%[45/58], P<0.001). Overall, serum HBV pgRNA strongly correlated with HBcrAg (r=0.760, P<0.001), and moderately correlated with HBV DNA (r=0.663, P<0.001) and HBsAg (r=0.670, P<0.001). As compared to HBsAg and HBV DNA, only HBcrAg showed stable correlation with serum HBV pgRNA both in HBeAg-positive and HBeAg-negative patients.
Conclusions: Serum HBV pgRNA level differed between HBeAg-positive and HBeAg-negative patients; and it had better and more stable correlation with serum HBcrAg than serum HBV DNA and HBsAg, irrespective of HBeAg status. This article is protected by copyright. All rights reserved.
Keywords: Correlation; Distribution; Hepatitis B virus core-related antigen; Serum HBV pregenomic RNA; hepatitis B surface antigen.
This article is protected by copyright. All rights reserved. 作者: StephenW 时间: 2020-9-20 20:17