. 2020 Aug 13;15(8):e0236704.
doi: 10.1371/journal.pone.0236704. eCollection 2020.
A recombinant human immunoglobulin with coherent avidity to hepatitis B virus surface antigens of various viral genotypes and clinical mutants
Gi Uk Jeong 1 , Byung-Yoon Ahn 1 , Jaesung Jung 2 , Hyunjin Kim 2 , Tae-Hee Kim 2 , Woohyun Kim 2 , Ara Lee 2 , Kyuhyun Lee 3 , Jung-Hwan Kim 2
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PMID: 32790777 DOI: 10.1371/journal.pone.0236704
Abstract
The hepatitis B virus (HBV) envelope is composed of a lipid bilayer and three glycoproteins, referred to as the large (L), middle (M), and small (S) hepatitis B virus surface antigens (HBsAg). S protein constitutes the major portion of the viral envelope and an even greater proportion of subviral particles (SVP) that circulate in the blood. Recombinant S proteins are currently used as a preventive vaccine, while plasma fractions isolated from vaccinated people, referred to as hepatitis B immune globulin (HBIG), are used for short-term prophylaxis. Here, we characterized a recombinant human IgG1 type anti-S antibody named Lenvervimab regarding its binding property to a variety of cloned S antigens. Immunochemical data showed an overall consistent avidity of the antibody to S antigens of most viral genotypes distributed worldwide. Further, antibody binding was not affected by the mutations in the antigenic 'a' determinant found in many clinical variants, including the immune escape mutant G145R. In addition, mutations in the S gene sequence that confer drug resistance to the viral polymerase did not interfere with the antibody binding. These results support for a preventive use of the antibody against HBV infection. 作者: StephenW 时间: 2020-8-15 19:55
。 2020年8月13日； 15（8）：e0236704。
doi：10.1371 / journal.pone.0236704。 eCollection 2020。
具有对各种病毒基因型和临床突变体的乙肝病毒表面抗原具有连贯亲和力的重组人免疫球蛋白
Gi Uk Jeong 1，Bing-Yoon Ahn 1，Jaesung Jung 2，Hyunjin Kim 2，Tae-Hee Kim 2，Woohyun Kim 2，Ara Lee 2，Kyuhyun Lee 3，Jung-Hwan 2
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