Efficacy and safety of continuous antiviral therapy from preconception to prevent perinatal transmission of hepatitis B virus
Xingfei Pan 1 , Jingsi Chen 2 3 4 , Liyang Zhou 1 , Xueting Ou 1 , Fang He 4 5 , Yifen Liu 4 5 , Shuo Zheng 1 , Haibin Wang 6 , Bin Cao 6 , Zhijian Wang 7 , Huishu Liu 8 , Guocheng Liu 9 , Zhenyu Huang 10 , Guanxin Shen 11 , Shiliang Liu 12 13 , Dunjin Chen 14 15 16
Affiliations
PMID: 32788743 DOI: 10.1038/s41598-020-70644-4
Abstract
Few studies were conducted to assess safety and efficacy of continuous antiviral therapy administrated from preconception. In the present study, 136 eligible women with chronic HBV infection were recruited, and assigned to active chronic hepatitis B (CHB) (Group A, B or C) or chronic HBV carrier (Group D). Antiviral therapy was administrated in preconception (Group A), in early (Group B) or late pregnancy (Group C and Group D). Immunoprophylaxis was administrated to all infants. Mothers' HBV status and ALT were assessed at delivery and 7 months postpartum. Offspring's HBV status was examined at 7 months old. Group A women showed low HBV DNA level and normal ALT throughout pregnancy. All women at delivery had an HBV DNA level of less than 106 IU/ml, but the proportion of patients with lower HBV DNA level in Group A was higher than any of other three groups (P < 0.05). No differences in obstetrical complications were found among the four groups. None of infants who completed follow-up showed positive HBsAg at age of 7 months. Congenital malformation and infant growth indicators were similar among study cohorts. Continuous antiviral therapy from preconception to entire pregnancy is effective and safe for active CHB mothers and their infants. 作者: StephenW 时间: 2020-8-14 13:46