乙型肝炎病毒X蛋白（HBx）失调的MicroRNA在乙型肝炎病毒相关

StephenW

The Multiple Roles of Hepatitis B Virus X Protein (HBx) Dysregulated MicroRNA in Hepatitis B Virus-Associated Hepatocellular Carcinoma (HBV-HCC) and Immune Pathways
Kurt Sartorius  1   2   3 , Leo Swadling  4 , Ping An  5 , Julia Makarova  6 , Cheryl Winkler  5 , Anil Chuturgoon  2 , Anna Kramvis  7
Affiliations
Affiliations

    1
    Faculty of Commerce, Law and Management, University of the Witwatersrand, Johannesburg 2050, South Africa.
    2
    Department of Public Health Medicine, School of Nursing and Public Health, University of KwaZulu-Natal, Durban 4041, South Africa.
    3
    UKZN Gastrointestinal Cancer Research Centre, Durban 4041, South Africa.
    4
    Division of Infection and Immunity, University College London, London WC1E6BT, UK.
    5
    Basic Research Laboratory, Centre for Cancer Research, National Cancer Institute, Leidos Biomedical Research, Inc. Frederick Nat. Lab. for Cancer Research, Frederick, MD 20878, USA.
    6
    National Research University Higher School of Economics, Faculty of Biology and Biotechnology, 10100 Moscow, Russia.
    7
    Hepatitis Virus Diversity Research Unit, Department of Internal Medicine, School of Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg 2050, South Africa.

    PMID: 32664401 DOI: 10.3390/v12070746

Abstract

Currently, the treatment of hepatitis B virus (HBV)-associated hepatocellular carcinoma (HCC) [HBV-HCC] relies on blunt tools that are unable to offer effective therapy for later stage pathogenesis. The potential of miRNA to treat HBV-HCC offer a more targeted approach to managing this lethal carcinoma; however, the complexity of miRNA as an ancillary regulator of the immune system remains poorly understood. This review examines the overlapping roles of HBx-dysregulated miRNA in HBV-HCC and immune pathways and seeks to demonstrate that specific miRNA response in immune cells is not independent of their expression in hepatocytes. This interplay between the two pathways may provide us with the possibility of using candidate miRNA to manipulate this interaction as a potential therapeutic option.

Keywords: HBx protein; dysregulated; hepatitis B virus; hepatocellular carcinoma; microRNA.

StephenW

乙型肝炎病毒X蛋白（HBx）失调的MicroRNA在乙型肝炎病毒相关的肝细胞癌（HBV-HCC）和免疫途径中的多重作用
Kurt Sartorius 1 2 3，Leo Swadling 4，平安5，Julia Makarova 6，Cheryl Winkler 5，Anil Chuturgoon 2，Anna Kramvis 7
隶属关系
隶属关系

    1个
    威特沃特斯兰德大学商业，法律和管理学院，南非约翰内斯堡2050。
    2
    夸祖鲁-纳塔尔大学护理与公共卫生学院公共卫生医学系，南非德班4041。
    3
    UKZN胃肠道癌研究中心，南非德班4041。
    4
    伦敦大学学院感染与免疫学系，英国伦敦WC1E6BT。
    5
    Leidos Biomedical Research，Inc.国家癌症研究所，癌症研究中心基础研究实验室。Frederick Nat。实验室美国癌症研究基金会，弗雷德里克，医学博士20878。
    6
    国立研究大学经济学院，生物与生物技术学院，俄罗斯莫斯科10100。
    7
    威特沃特斯兰德大学健康科学学院临床医学院内科肝炎病毒多样性研究室，南非约翰内斯堡2050。

    PMID：32664401 DOI：10.3390 / v12070746

抽象

当前，与乙型肝炎病毒（HBV）相关的肝细胞癌（HCC）[HBV-HCC]的治疗依赖于钝器，这些钝器无法为晚期发病机理提供有效的治疗方法。 miRNA在治疗HBV-HCC中的潜力为治疗这种致命癌提供了更有针对性的方法。然而，miRNA作为免疫系统辅助调节剂的复杂性仍然知之甚少。这篇综述检查了HBx失调的miRNA在HBV-HCC和免疫途径中的重叠作用，并试图证明免疫细胞中的特定miRNA反应并不独立于其在肝细胞中的表达。两种途径之间的相互作用可能为我们提供使用候选miRNA操纵这种相互作用作为潜在治疗选择的可能性。

关键字：HBx蛋白；失调乙型肝炎病毒;肝细胞癌；微小RNA。

StephenW

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