Patterns of HBeAg, HBsAg clearance among a treatment-naive Alaskan cohort in a long-term observational study
Journal of Viral Hepatitis — Shah PA, et al. | February 12, 2020
Researchers conducted a long-term observational study in a cohort of patients with HBeAg (+) and (-) chronic hepatitis B (CHB) who achieved spontaneous HBsAg clearance CHB for assessing the patterns of HBsAg reduction in these patients. From an antiviral treatment-naive Alaska Native population who achieved HBsAg seroclearance from 1973 to 2009 with samples at least 2 years prior to HBsAg loss, they selected 17 HBeAg (+) and 48 HBeAg (-) patients with predominantly HBV genotypes D and F. The analysis revealed a significantly slower rate of HBsAg clearance among the HBeAg (+) patients. HBeAg (-) patients exhibited more uniform loss of HBsAg loss at a rate of about 4% over 25 years. The HBeAg (+) patients exhibited a similar average decline in HBeAg (1.8 log IU/ml/year) and HBsAg (1.5 log IU/ml /year) from baseline to HBeAg loss. They observed a significantly faster rate of HBsAg reduction before (1.5 log IU/ml/year) compared with after (0.4 log IU/ml /year) HBeAg clearance. A similar kinetic of HBsAg decline was noted after HBeAg loss to that noted among the HBeAg (-) patients (0.3 log IU/ml /year). A biphasic decline in HBsAg titers prior to and after HBeAg seroclearance is identified as a novel finding. Findings suggest that valuable information on the natural course of CHB could be gained via HBsAg quantification over time. Its kinetic may assist in predicting HBsAg loss particularly in the HBeAg (-) phase of CHB. 作者: StephenW 时间: 2020-2-13 12:41
一项长期观察研究中未接受过治疗的阿拉斯加人群中HBeAg，HBsAg清除的模式
病毒性肝炎杂志— Shah PA等。 | 2020年2月12日
研究人员对一群HBeAg（+）和（-）慢性乙型肝炎（CHB）的患者进行了长期观察性研究，这些患者实现了自发HBsAg清除率CHB，以评估这些患者的HBsAg减少模式。他们从1973年至2009年间获得抗HBsAg血清清除率的未接受过抗病毒治疗的阿拉斯加原住民中，至少在HBsAg丢失前两年就获得了样本，他们选择了17例HBeAg（+）和48例HBeAg（-）患者，其主要为HBV基因型D和F.分析显示，HBeAg（+）患者的HBsAg清除率明显降低。 HBeAg（-）患者在25年中表现出更均匀的HBsAg损失，比率约为4％。从基线到HBeAg损失，HBeAg（+）患者的HBeAg（1.8 log IU / ml /年）和HBsAg（1.5 log IU / ml /年）平均下降相似。他们观察到，HBsAg清除之前（1.5 log IU / ml /年）的HBsAg清除率比清除后（0.4 log IU / ml /年）的HBsAg清除率明显更快。 HBeAg丢失后，HBsAg下降的动力学与HBeAg（-）患者之间相似（0.3 log IU / ml /年）。在HBeAg血清清除之前和之后，HBsAg滴度双相下降被认为是一个新发现。研究结果表明，随着时间的流逝，可通过HBsAg定量获得有关CHB自然病程的有价值的信息。它的动力学可能有助于预测HBsAg的损失，尤其是在CHB的HBeAg（-）期。