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标题: 病毒学缓解时血清Mac-2-结合蛋白糖基化异构体可预测慢性乙 [打印本页]

作者: StephenW 时间: 2019-10-6 19:51 标题: 病毒学缓解时血清Mac-2-结合蛋白糖基化异构体可预测慢性乙

                                 Serum Mac-2-binding protein glycosylation isomer at virological remission predicts hepatocellular carcinoma and death in chronic hepatitis B related cirrhosis                                                                                                                                  [url=]Tung-Hung Su, MD[/url],                                                                                                       [url=]Cheng-Yuan Peng, MD[/url],                                                                                                       [url=]Tai-Chung Tseng, MD[/url],                                                                                                       [url=]Hung-Chih Yang, MD[/url],                                                                                                       [url=]Chun-Jen Liu, MD[/url],                                                                                                       [url=]Chen-Hua Liu, MD[/url],                                                                                                       [url=]Pei-Jer Chen, MD[/url],                                                                                                       [url=]Ding-Shinn Chen, MD[/url],                                                                                                       [url=]Jia-Horng Kao, MD[/url]


                  The Journal of Infectious Diseases, jiz496, https://doi.org/10.1093/infdis/jiz496

                                 Published:
            01 October 2019

            [url=]Article history[/url]

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                                             AbstractBackground
To investigate serum Mac-2-binding protein glycosylation isomer (M2BPGi) levels in predicting hepatocellular carcinoma (HCC) and mortality at virological remission (VR, HBV DNA <20 IU/mL) following antiviral therapy in chronic hepatitis B (CHB) patients with cirrhosis.
Methods
This retrospective cohort study included patients with CHB-related Child-Pugh A cirrhosis undergoing long-term antiviral therapy. Serum M2BPGi levels were quantified and multivariable Cox proportional hazards regression models were used to identify risk predictors for HCC and death.
Results
A total of 126 and 145 patients were included in the derivation and validation cohorts, respectively. The mean age was 56, and the mean M2BPGi level was 1.86 cut-off index (COI) in the derivation cohort. After adjustment for confounders, a higher M2BPGi level at VR significantly predicted HCC (hazard ratio [HR]: 1.58, 95% confidence interval [CI]: 1.19-2.10, P=0.002) and death (HR: 2.17, 95% CI: 1.02-4.62, P=0.044). The M2BPGi ≥3 COI significantly increased the risk of HCC and death in the derivation and validation cohorts. Serial M2BPGi levels declined significantly (P=0.0001) in non-HCC patients only, and remained significantly lower than those who developed HCC afterwards (P=0.039).
Conclusions
Serum M2BPGi levels at antiviral therapy-induced VR predict HCC development and death in patients with CHB-related Child-Pugh A cirrhosis.

作者: StephenW 时间: 2019-10-6 19:52

病毒学缓解时血清Mac-2-结合蛋白糖基化异构体可预测慢性乙型肝炎相关肝硬化的肝细胞癌和死亡
苏东雄医师，彭成元医师，曾大中医师，杨鸿志医师，刘春仁医师，刘晨华医师，陈佩杰医师，丁医师-医学博士陈欣（Shinn Chen），高嘉-（Kajia-Horng）
传染病杂志，jiz496，https://doi.org/10.1093/infdis/jiz496
发布时间：
2019年10月01日
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抽象
背景

目的探讨慢性Mac乙型肝炎（CHB）患者抗病毒治疗后血清Mac-2-结合蛋白糖基化异构体（M2BPGi）水平在预测肝细胞癌（HCC）和病毒缓解后的死亡率（VR，HBV DNA <20 IU / mL）的情况。肝硬化。
方法

这项回顾性队列研究包括接受长期抗病毒治疗的CHB相关性Child-Pugh A肝硬化患者。量化血清M2BPGi水平，并使用多变量Cox比例危险性回归模型确定HCC和死亡的风险预测因子。
结果

分别有126位和145位患者被包括在派生和验证队列中。在该衍生队列中，平均年龄为56岁，平均M2BPGi水平为1.86临界值（COI）。调整混杂因素后，VR处较高的M2BPGi水平可显着预测HCC（危险比[HR]：1.58，95％置信区间[CI]：1.19-2.10，P = 0.002）和死亡（HR：2.17，95％CI： 1.02-4.62，P = 0.044在衍生和验证队列中，M2BPGi≥3COI显着增加了HCC和死亡的风险；仅非HCC患者的连续M2BPGi水平显着下降（P = 0.0001），并且仍显着低于那些后来发展为HCC的人（P = 0.039）。
结论

抗病毒治疗诱发的VR的血清M2BPGi水平可预测CHB相关性Child-Pugh A肝硬化患者的肝癌发生和死亡。

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