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标题: 乙型肝炎对非酒精性脂肪性肝病患者代谢综合征的保护作用 [打印本页]

作者: StephenW    时间: 2019-9-24 17:52     标题: 乙型肝炎对非酒精性脂肪性肝病患者代谢综合征的保护作用

Metab Syndr Relat Disord. 2019 Sep 23. doi: 10.1089/met.2019.0032. [Epub ahead of print]
Protective Effect of Hepatitis B Against Metabolic Syndrome in Patients with Nonalcoholic Fatty Liver Disease But Not in Normal Individuals.
Pei C1, Wu CZ2,3, Hsieh CH4, Chang JB5, Liang YJ6, Chen YL7, Pei D8, Lin JD2,3.
Author information

1
    Department of Rehabilitation Treatment, School of Medical Technology and Engineering, Fujian Medical University, Fuzhou, China.
2
    Division of Endocrinology, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan, ROC.
3
    Division of Endocrinology and Metabolism, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, New Taipei City, Taiwan, ROC.
4
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical School, Taipei, Taiwan, ROC.
5
    Department of Pathology, National Defense Medical Center, Division of Clinical Pathology, Tri-Service General Hospital, Taipei, Taiwan, ROC.
6
    Department and Institute of Life Science, Fu Jen Catholic University, New Taipei City, Taiwan, ROC.
7
    Department of Pathology, Cardinal Tien Hospital, School of Medicine, Catholic Fu Jen University, Taipei, Taiwan, ROC.
8
    Department of Internal Medicine, Fu Jen Catholic Hospital, School of Medicine, Catholic Fu Jen University, Taipei, Taiwan, ROC.

Abstract

Background: Both hepatitis B (HB) and nonalcoholic fatty liver disease (NAFLD) are related to metabolic syndrome (MetS); however, this relationship remains controversial. In this study, we determined the effects of NAFLD and HB infection on the risk of MetS among elderly individuals. Methods: In total, 24,500 individuals aged >65 years were enrolled; they were classified into four groups: normal individuals (N), patients with only HB infection without abnormal echogenicity (HB-alone), patients with only abnormal echogenicity or fatty liver alone (FL-alone), and patients with both HB infection and abnormal echogenicity (HB-FL). Results: After adjustment for age, compared with group N, men and women with NAFLD (FL-alone and HB-FL) had a significantly higher risk of MetS, whereas no significant difference was observed in the incidence of MetS between groups HB-alone and N. However, group HB-FL had a lower risk of MetS than did group FL-alone. HB infection (HB-alone and HB-FL) was associated with a lower risk of high triglycerides (TGs) and fasting plasma glucose (FPG) than HB infection absence (groups N and FL-alone) in men and women. Lower risk of TG derangement was observed in group HB-alone than in group N. In addition, both men and women in group HB-FL had a lower risk of TG and FPG abnormalities than in group FL-alone, whereas a decrease in incidence of high waist circumference and blood pressure was observed only in men. Conclusion: HB infection protects against MetS development, only in patients with HB infection and NAFLD, but not in normal individuals. Additional studies are warranted to clarify the pathogenesis.
KEYWORDS:

fasting plasma glucose; hepatitis B; metabolic syndrome; nonalcoholic fatty liver disease; triglyceride

PMID:
    31545133
DOI:
    10.1089/met.2019.0032


作者: StephenW    时间: 2019-9-24 17:53

Metab Syndr Relat Disord。 2019年9月23日.doi:10.1089 / met.2019.0032。 [Epub提前发布]
乙型肝炎对非酒精性脂肪性肝病患者代谢综合征的保护作用,但对正常人却没有。
裴C1,吴CZ2,3,谢CH4,张JB5,梁YJ6,陈YL7,裴D8,林JD2,3。
作者信息

1
    福建医科大学医学技术与工程学院康复治疗系,福州。
2
    中华民国台湾省新北市台北医科大学双河医院内科,内科。
3
    中华民国台湾新北市台北医科大学医学院内科系内分泌代谢科。
4
    中华民国台北市国防医学院三军总医院内科内分泌代谢科。

    中华民国台北市三军总医院国防医学中心病理科,临床病理科。
6
    中华民国辅仁大学生命科学系和研究所。
7
    中华民国天主教辅仁大学医学院附属天恩医院病理科,台湾台北。
8
    中华民国天主教辅仁大学医学院附属辅仁大学附属医院内科。

抽象

背景:乙型肝炎(HB)和非酒精性脂肪肝疾病(NAFLD)均与代谢综合征(MetS)相关;但是,这种关系仍然存在争议。在这项研究中,我们确定了NAFLD和HB感染对老年人个体MetS风险的影响。方法:总共招募了24500名年龄在65岁以上的人;他们分为四类:正常个体(N),仅具有无回声原性的HB感染的患者(仅HB),仅具有回声原性或单独的脂肪肝的患者(仅FL)以及既有HB感染又有异常的患者回声(HB-FL)。结果:调整年龄后,与N组相比,NAFLD的男性和女性(仅FL和HB-FL)患MetS的风险明显更高,而仅HB组之间MetS的发生率没有显着差异但是,HB-FL组的MetS风险比单独FL组低。与没有HB感染(仅N和FL组)的男性和女性相比,HB感染(仅HB和HB-FL)与高甘油三酸酯(TGs)和空腹血糖(FPG)的风险较低。单独使用HB组的人发生TG紊乱的风险要比单独使用N组的人低。此外,与单独使用FL组的人相比,HB-FL组的男性和女性的TG和FPG异常发生的风险要低,而发生率却降低仅在男性中观察到高腰围和血压下降。结论:HB感染仅在患有HB感染和NAFLD的患者中阻止MetS的发展,而在正常个体中则不能。有必要进行进一步的研究以阐明发病机理。
关键词:

空腹血糖乙型肝炎;代谢综合征;非酒精性脂肪肝疾病;甘油三酯

结论:
    31545133
DOI:
    10.1089 / met.2019.0032




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