Fibrosis evolution in chronic hepatitis B e antigen-negative patients across a 10‐year interval
Lung‐Yi Mak
Wai‐Kay Seto
Rex Wan‐Hin Hui
James Fung
Danny Ka‐Ho Wong
Ching‐Lung Lai
Man‐Fung Yuen
First published: 21 March 2019 Https://doi.org/10.1111/jvh.13095
Funding information:
This study was supported by the SK Yee Medical Foundation (ref no: 2151210) and the Hong Kong Association for the Study of Liver Dieases Young Investigator Research Grant 2015.
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Summary
The study of to influence the evolution of liver fibrosis in CHB across a 10‐year Period. CHB patients with liver stiffness measurement (LSM) by transient elastography 10 years ago were recruited for follow‐up LSM. Fibrosis progression/regression was arbitrarily defined as ≥1 fibrosis stage change from Baseline. A total of 459 hepatitis B e antigen (HBeAg)-negative patients (224 untreated, 235 treated with nucleos(t)ide analogues [NAs]) were recruited. The mean age at baseline LSM was 41.7 ± 9.0 years (56.2% Over 10 years, the proportion of patients with advanced fibrosis/cirrhosis significantly reduced from 16.3% to 5.7% (P < 0.001). Fibrosis progression and regression were observed in 8.7% and 37.5%, respectiv Ely. No treatment with NAs (OR 2.259, 95% confidence interval [CI]: 1.032‐4.945), metabolic syndrome (OR 4.379, 95% CI: 1.128‐16.999) and hepatic steatosis (OR 7.799, 95% CI: 2.271‐ 26.776) was associated with fibrosis progression. Liver stiffness decline artwork positive correlation with the time after HBsAg seroclearance (r = −0.50, P < 0.001). Median liver stiffness was higher both at baseline (14.0 vs 6 kPa, P < 0.001) and 10 years (9.1 vs 4.9 kPa, P < 0.001) in patients with cirrhosis‐related complications/hepatocellular carcinoma compared with those without. In conclusion, CHB‐related liver fibrosis changed dynamically across 10 years. Metabolic syndrome and hepatic steatosis were associated with fibrosis Progression, while antiviral therapy was associated with fibrosis regression. Patients with HBsAg seroclearance demonstrat time-dependent decline in liver stiffness.作者: StephenW 时间: 2019-4-20 14:52
慢性乙型肝炎e抗原阴性患者的纤维化进展,间隔10年
龙益麦
Wai-Kay Seto
Rex Wan-Hin Hui
詹姆斯冯
Danny Ka-Ho Wong
黎庆龙
万凤媛
首次发表:2019年3月21日 Https://doi.org/10.1111/jvh.13095