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标题: 一种新的诊断算法，用于预测可检测到的HBV DNA和持续正常的 [打印本页]

作者: StephenW 时间: 2018-10-21 11:03 标题: 一种新的诊断算法，用于预测可检测到的HBV DNA和持续正常的

Sci Rep. 2018 Oct 18;8(1):15449. doi: 10.1038/s41598-018-33412-z.
A novel diagnostic algorithm to predict significant liver inflammation in chronic hepatitis B virus infection patients with detectable HBV DNA and persistently normal alanine transaminase.
Li Q1, Zhou Y2, Huang C3, Li W3, Chen L4.
Author information
Abstract

Significant liver inflammation might be found in 20-34% of chronic hepatitis B virus (HBV) infection patients with detectable HBV DNA and persistently normal alanine transaminase (ALT) (PNALT). We aimed to develop a diagnostic algorithm to predict significant liver inflammation in these specific patients. Using liver biopsy as the gold standard, we developed a novel, simple diagnostic algorithm to predict significant liver inflammation in a training set of 365 chronic HBV infection patients with detectable HBV DNA and PNALT, and validated the diagnostic accuracy in a validation set of 164 similar patients. The novel algorithm (AAGP) attributed to age, ALT, gamma-glutamyl transpeptidase (GGT), and platelet count was developed. In the training set, the area under the receiver operating characteristic curve (AUROC) of AAGP was higher than that of ALT and aspartate transaminase (AST), to diagnose significant liver inflammation (0.77, 0.67, and 0.59, respectively, p < 0.001). In the validation set, the AUROC of AAGP was also higher than ALT and AST (0.75, 0.61, and 0.54, respectively, p < 0.001). Using AAGP ≥2, the sensitivity and negative predictive value (NPV) was 91% and 93%, respectively, to diagnose significant liver inflammation. Using AAGP ≥8, the specificity and NPV was 91% and 86%, respectively, for significant liver inflammation. In conclusion, the AAGP algorithm is a novel, simple, user-friendly algorithm for the diagnosis of significant liver inflammation in chronic HBV infection patients with detectable HBV DNA and PNALT.

PMID:
30337643
DOI:
10.1038/s41598-018-33412-z

作者: StephenW 时间: 2018-10-21 11:04

Sci Rep.2018 Oct 18; 8（1）：15449。 doi：10.1038 / s41598-018-33412-z。
一种新的诊断算法，用于预测可检测到的HBV DNA和持续正常的丙氨酸转氨酶的慢性乙型肝炎病毒感染患者的显着肝脏炎症。
Li Q1，Zhou Y2，Huang C3，Li W3，Chen L4。
作者信息
抽象

在具有可检测的HBV DNA和持续正常的丙氨酸转氨酶（ALT）（PNALT）的慢性乙型肝炎病毒（HBV）感染患者中，20-34％可能发现显着的肝脏炎症。我们的目标是开发一种诊断算法，以预测这些特定患者的明显肝脏炎症。使用肝脏活组织检查作为金标准，我们开发了一种新颖，简单的诊断算法，用于预测365例慢性HBV感染患者的HBV DNA和PNALT可检测的显着肝脏炎症，并在164个类似的验证集中验证诊断准确性耐心。开发了归因于年龄，ALT，γ-谷氨酰转肽酶（GGT）和血小板计数的新算法（AAGP）。在训练集中，AAGP接受者操作特征曲线（AUROC）下的面积高于ALT和天冬氨酸转氨酶（AST），以诊断显着的肝脏炎症（分别为0.77,0.67和0.59，p <0.001）。在验证集中，AAGP的AUROC也高于ALT和AST（分别为0.75,0.61和0.54，p <0.001）。使用AAGP≥2时，敏感性和阴性预测值（NPV）分别为91％和93％，用于诊断明显的肝脏炎症。使用AAGP≥8时，显着肝脏炎症的特异性和NPV分别为91％和86％。总之，AAGP算法是一种新颖，简单，用户友好的算法，用于诊断具有可检测的HBV DNA和PNALT的慢性HBV感染患者的显着肝脏炎症。

结论：
30337643
DOI：
10.1038 / s41598-018-33412-Z
Sci Rep.2018 Oct 18; 8(1):15449. Doi:10.1038/ S41598-018-33412-z.
Yī zhǒng xīn de zhěnduàn suànfǎ, yòng yú yùcè kě jiǎncè dào de HBV DNA hé chíxù zhèngcháng de bǐng ān suān zhuǎn'ānméi de mànxìng yǐ xíng gānyán bìngdú gǎnrǎn huànzhě de xiǎnzhe gānzàng yánzhèng.
Li Q1,Zhou Y2,Huang C3,Li W3,Chen L4.
Zuòzhě xìnxī
chōuxiàng

zài jùyǒu kě jiǎncè de HBV DNA hé chíxù zhèngcháng de bǐng ān suān zhuǎn'ānméi (ALT)(PNALT) de mànxìng yǐ xíng gānyán bìngdú (HBV) gǎnrǎn huànzhě zhōng,20-34%kěnéng fāxiàn xiǎnzhe de gānzàng yánzhèng. Wǒmen de mùbiāo shì kāifā yī zhǒng zhěnduàn suànfǎ, yǐ yùcè zhèxiē tèdìng huànzhě de míngxiǎn gānzàng yánzhèng. Shǐyòng gānzàng huó zǔzhī jiǎnchá zuòwéi jīn biāozhǔn, wǒmen kāifāle yī zhǒng xīnyǐng, jiǎndān de zhěnduàn suànfǎ, yòng yú yùcè 365 lì mànxìng HBV gǎnrǎn huànzhě de HBV DNA hé PNALT kě jiǎncè de xiǎnzhe gānzàng yánzhèng, bìng zài 164 gè lèisì de yànzhèng jízhōng yànzhèng zhěnduàn zhǔnquè xìng nàixīn. Kāifāle guī yīn yú niánlíng,ALT,g-gǔ ān xiān zhuǎn tài méi (GGT) hé xuèxiǎobǎn jì shǔ de xīn suànfǎ (AAGP). Zài xùnliàn jízhōng,AAGP jiēshòu zhě cāozuò tèzhēng qūxiàn (AUROC) xià de miànjī gāo yú ALT hé tiān dōng ān suān zhuǎn'ānméi (AST), yǐ zhěnduàn xiǎnzhe de gānzàng yánzhèng (fēnbié wèi 0.77,0.67 Hé 0.59,P <0.001). Zài yànzhèng jízhōng,AAGP de AUROC yě gāo yú ALT hé AST(fēnbié wèi 0.75,0.61 Hé 0.54,P <0.001). Shǐyòng AAGP≥2 shí, mǐngǎn xìng hé yīnxìng yùcè zhí (NPV) fēnbié wèi 91%hé 93%, yòng yú zhěnduàn míngxiǎn de gānzàng yánzhèng. Shǐyòng AAGP≥8 shí, xiǎnzhe gānzàng yánzhèng de tèyì xìng hé NPV fēnbié wèi 91%hé 86%. Zǒngzhī,AAGP suànfǎ shì yī zhǒng xīnyǐng, jiǎndān, yònghù yǒuhǎo de suànfǎ, yòng yú zhěnduàn jùyǒu kě jiǎncè de HBV DNA hé PNALT de mànxìng HBV gǎnrǎn huànzhě de xiǎnzhe gānzàng yánzhèng.

Jiélùn:
30337643
DOI:
10.1038/ S41598-018-33412-Z

作者: StephenW 时间: 2018-10-21 11:04

https://www.nature.com/articles/s41598-018-33412-z

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