Mol Med Rep. 2018 Jul 30. doi: 10.3892/mmr.2018.9336. [Epub ahead of print]
Diagnostic utility of plasma lncRNA small nucleolar RNA host gene 1 in patients with hepatocellular carcinoma.
Gao S1, Xu X2, Wang Y3, Zhang W1, Wang X2.
Author information
1
Department of Oncology, The Third Affiliated Hospital of Qiqihar Medical University, Qiqihar, Heilongjiang 161021, P.R. China.
2
Department of Clinical Laboratory, The Third Affiliated Hospital of Qiqihar Medical University, Qiqihar, Heilongjiang 161021, P.R. China.
3
Medical School of Nanchang University, Nanchang, Jiangxi 330031, P.R. China.
Abstract
Long non‑coding RNAs (lncRNAs) offer great potential as cancer biomarkers. Owing to the limited sensitivity and specificity of α‑fetoprotein (AFP) for the diagnosis of hepatocellular carcinoma (HCC), the present study used an lncRNA microarray to screen aberrantly expressed lncRNAs in HCC tissues. Subsequently, the expression profile of the target lncRNAs was investigated in plasma from patients with HCC or hepatitis B virus‑positive chronic hepatitis and cirrhosis (HCH), as well as from healthy volunteers. A total of six aberrantly expressed lncRNAs were identified in HCC tissues and corresponding normal tissues, from which only small nucleolar RNA host gene 1 (SNHG1) expression in HCC tissues demonstrated a good correlation with those in plasma from HCC patients. Subsequent analysis revealed that high plasma SNHG1 expression levels were correlated with tumor size, TNM stage and AFP levels. Receiver operating characteristic analysis demonstrated that SNHG1 yields an excellent diagnostic ability to differentiate between patients with HCC and unaffected control patients, which was superior to that of AFP. The combination of SNHG1 with AFP may be able to distinguish HCC from HCH or healthy volunteers with the area under the curve values of 0.86 and 0.97, respectively. In summary, it was demonstrated that plasma SNHG1 has great potential as a sensitive and reliable biomarker for the diagnosis of HCC.
PMID:
30066898
DOI:
10.3892/mmr.2018.9336
作者: StephenW 时间: 2018-8-3 15:41
Mol Med Rep.2018 7月30日doi：10.3892 / mmr.2018.9336。 [提前打印]
血浆lncRNA小核仁RNA宿主基因1在肝细胞癌诊断中的应用。
高S1，徐X2，王Y3，张文1，王X2。
作者信息