Tumor necrosis factor receptor superfamily 2 (TNFR2) plays an important role in controlling the progression of antiviral and antitumorr. Evidence suggests that TNFR2 is involved in the pathogenesis of HBV-induced liver injury. We therefore examined whether TNFR2 polymorphisms are associated with the risk of HBV-related liver disease in Chinese population. In this case-control study, 115 chronic hepatitis B (CHB) patients, 86 HBV-related liver cirrhosis patients (LC), 272 HBV-related hepatocellular carcinoma patients (HCC) and 269 healthy controls were recruited. TNFR2 rs1061622 and rs1061624 polymorphisms were examined using a polymerase chain reaction-restriction fragment length polymorphism analysis. Binary logistic regression analyses revealed that the A allele of rs1061624 was positively associated with the risk of CHB (AA vs. GG, P = 0.026; AA vs. GA+GG, P = 0.021), LC (AA vs. GG, P = 0.027; AA+GA vs. GG, P = 0.036), and HCC (GA vs. GG, P = 0.046; GA+AA vs. GG, P = 0.031). Moreover, subgroup analysis indicated that male subjects have increased risk in developing CHB and LC. Nevertheless, no association was found between rs1061622 polymorphism and HBV-related liver diseases in the overall or subgroup analyses. Our retrospective study suggests that the TNFR2 rs1061624 polymorphism is associated with HBV-related CHB, LC, and HCC in Chinese population, particularly in males.作者: StephenW 时间: 2018-6-19 21:31
TNFR基因多态性与中国人群乙型肝炎病毒相关性肝病危险性的关系
马丽萍陈思远毛小环吕露张小连老贤君薛琴李珊
科学报告卷8，文章编号：9240（2018）|下载引文
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肿瘤坏死因子受体超家族2（TNFR2）在控制抗病毒药物和抗肿瘤药物的进展中发挥重要作用。有证据表明TNFR2参与HBV诱导的肝损伤的发病机制。因此，我们检查了TNFR2多态性是否与中国人群中HBV相关肝病的风险相关。在此病例对照研究中，招募了115名慢性乙型肝炎（CHB）患者，86名HBV相关肝硬化患者（LC），272名HBV相关肝细胞癌患者（HCC）和269名健康对照。采用聚合酶链反应 - 限制性片段长度多态性分析检测TNFR2 rs1061622和rs1061624多态性。二元logistic回归分析显示rs1061624的A等位基因与CHB风险呈正相关（AA vs. GG，P = 0.026; AA vs. GA + GG，P = 0.021），LC（AA vs. GG，P = 0.027; AA + GA对GG，P = 0.036）和HCC（GA对GG，P = 0.046; GA + AA对GG，P = 0.031）。此外，亚组分析表明男性受试者发展CHB和LC的风险增加。然而，在整体或亚组分析中，rs1061622多态性与HBV相关肝病之间没有发现关联。我们的回顾性研究表明TNFR2 rs1061624多态性与中国人群中与HBV相关的CHB，LC和HCC相关，特别是在男性中。作者: StephenW 时间: 2018-6-19 21:32