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标题: 关键的HLA-DRB1-DQB1单倍型和BTNL2基因对乙肝疫苗应答的作用。 [打印本页]

作者: smilingcloud 时间: 2018-4-12 03:28 标题: 关键的HLA-DRB1-DQB1单倍型和BTNL2基因对乙肝疫苗应答的作用。

[size=0.8465em]Hepatology. 2018 Mar 13. doi: 10.1002/hep.29876. [Epub ahead of print]
Key HLA-DRB1-DQB1 haplotypes and role of the BTNL2 gene for response to a hepatitis B vaccine.[size=0.923em]Nishida N[size=0.8461em]1,[size=0.8461em]2, Sugiyama M[size=0.8461em]1, Sawai H[size=0.8461em]2, Nishina S[size=0.8461em]3, Sakai A[size=0.8461em]4, Ohashi J[size=0.8461em]5, Khor SS[size=0.8461em]2, Kakisaka K[size=0.8461em]6, Tsuchiura T[size=0.8461em]1, Hino K[size=0.8461em]3, Sumazaki R[size=0.8461em]4, Takikawa Y[size=0.8461em]6, Murata K[size=0.8461em]1,[size=0.8461em]7, Kanda T[size=0.8461em]8, Yokosuka O[size=0.8461em]8, Tokunaga K[size=0.8461em]2, Mizokami M[size=0.8461em]1.
[size=13.9997px]Author information

Abstract

Approximately 5-10% of individuals, who are vaccinated with a hepatitis B (HB) vaccine designed based on the HBV genotype C, fail to acquire protective levels of antibodies. Here, host genetic factors behind low immune response to this HB vaccine were investigated by a genome wide association study (GWAS) and HLA association tests. A GWAS and HLA association tests were carried out using a total of 1,193 Japanese individuals including 107 low responders, 351 intermediate responders, and 735 high responders. Classical HLA class II alleles were statistically imputed using the genome-wide SNP typing data. The GWAS identified independent associations of HLA-DRB1-DQB1, HLA-DPB1 and BTNL2 genes with immune response to a HB vaccine designed based on the HBV genotype C. Five HLA-DRB1-DQB1 haplotypes and two DPB1 alleles showed significant associations with response to the HB vaccine in a comparison of three groups of 1,193 HB vaccinated individuals. When frequencies of DRB1-DQB1 haplotypes and DPB1 alleles were compared between low immune responders and HBV patients, significant associations were identified for three DRB1-DQB1 haplotypes, and no association was identified for any of the DPB1 alleles. In contrast, no association was identified for DRB1-DQB1 haplotypes and DPB1 alleles in a comparison between high immune responders and healthy individuals. The findings in this study clearly show the importance of HLA-DR-DQ (i.e. recognition of a vaccine related HB surface antigen (HBsAg) by specific DR-DQ haplotypes) and BTNL2 molecules (i.e. high immune response to HB vaccine) for response to a HB vaccine designed based on the HBV genotype C. This article is protected by copyright. All rights reserved.

[size=0.923em]KEYWORDS:

GWAS; HBV; Vaccine; host genetic factors

作者: smilingcloud 时间: 2018-4-12 03:28

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考研[size=0.692em]美国国家医学图书馆美国国家卫生研究院

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发给

[size=0.8465em]肝病。2018年3月13日，doi：10.1002 / hep.29876。[电子版提前打印]
关键的HLA-DRB1-DQB1单倍型和BTNL2基因对乙肝疫苗应答的作用。[size=0.923em]西田Ñ [size=0.8461em]1，[size=0.8461em]2，杉山中号[size=0.8461em]1，泽井ħ [size=0.8461em]2，仁科小号[size=0.8461em]3，堺甲[size=0.8461em]4，大桥Ĵ [size=0.8461em]5，霍尔SS [size=0.8461em]2，Kakisakaķ [size=0.8461em]6，土浦Ť [size=0.8461em]1，日野ķ [size=0.8461em]3，Sumazaki - [R [size=0.8461em]4，滝川ÿ [size=0.8461em]6，村田ķ [size=0.8461em]1，[size=0.8461em]7，神田Ť [size=0.8461em]8，横须贺ö [size=0.8461em]8，德永ķ [size=0.8461em]2，Mizokami M [size=0.8461em]1。
[size=13.9997px]作者信息

抽象

大约5-10％接种了基于HBV基因型C设计的乙肝（HB）疫苗的个体未能获得抗体保护水平。在此，通过全基因组关联研究（GWAS）和HLA关联测试研究了针对该HB疫苗的低免疫应答背后的宿主遗传因子。使用总共1,193名日本人进行GWAS和HLA关联测试，其中包括107名低应答者，351名中间应答者和735名高应答者。使用全基因组SNP分型数据统计推断经典HLA II类等位基因。GWAS鉴定了HLA-DRB1-DQB1，HLA-DPB1和BTNL2基因与针对基于HBV基因型C设计的HB疫苗的免疫应答的独立关联。5个HLA-DRB1-DQB1单体型和2个DPB1等位基因显示与HB疫苗的反应显着相关，在三组1,193HB接种疫苗的个体中进行比较。当比较低免疫反应者和HBV患者中DRB1-DQB1单倍型和DPB1等位基因的频率时，三种DRB1-DQB1单倍型鉴定出显着相关性，并且没有发现任何DPB1等位基因的关联。相比之下，在高免疫应答者与健康个体之间的比较中未鉴定DRB1-DQB1单倍型和DPB1等位基因的关联。该研究中的发现清楚地显示了HLA-DR-DQ（即通过特异性DR-DQ单元型识别疫苗相关的HB表面抗原（HBsAg））和BTNL2分子（即对HB疫苗的高免疫应答）对基于HBV基因型C设计的HB疫苗的应答。本文受版权保护。版权所有。

[size=0.923em]关键词：

GWAS; HBV; 疫苗; 宿主遗传因素

作者: smilingcloud 时间: 2018-4-12 03:29

https://www.amed.go.jp/news/release_20180323.html

作者: MP4 时间: 2018-4-12 10:46

借道问一下日本的接种流程是两个月之后的吗？http://hbvhbv.info/forum/thread-1699862-1-1.html

作者: smilingcloud 时间: 2018-5-9 12:35

MP4 发表于 2018-4-12 10:46
借道问一下日本的接种流程是两个月之后的吗？http://hbvhbv.info/forum/thread-1699862-1-1.html
...

是的

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