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标题: 乙型肝炎病毒核衣壳组装的小分子抑制剂：治疗慢性HBV感染 [打印本页]

作者: StephenW 时间: 2017-7-6 17:30 标题: 乙型肝炎病毒核衣壳组装的小分子抑制剂：治疗慢性HBV感染

Curr Med Chem. 2017 Jul 4. doi: 10.2174/0929867324666170704121800. [Epub ahead of print]
Small molecule inhibitors of hepatitis B virus nucleocapsid assembly: a new approach to treat chronic HBV infection.Yang L1, Lu M2.
Author information
1Laboratory of Immunopharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai. China.2Institute of Virology, University Hospital Essen, University Duisburg Essen, Essen. Germany.

AbstractHepatitis B virus (HBV) infection is still a major health problem worldwide. The current available antiviral drugs for the treatment of chronic HBV infection do not achieve satisfactory results. Thus, it is desirable to develop novel anti-HBV drugs based the recent advances of basic research on molecular biology of HBV. HBV nucleocapsid assembly is now considered as a potential target of anti-HBV therapy. Structural and functional analysis provided essential insight of molecular interaction of the components of HBV nucleocapsid. Prototypes of small molecule modulators of HBV nucleocapsid assembly were developed and partly tested in clinical phase I. In the present review, the recent advances in HBV molecular biology and approach to develop inhibitors for anti-HBV treatment based on the disruption of viral nucleocapsids by either prevention of assembly or induction of misassembly will be summarized. We will discuss the future concepts of anti-HBV treatment based on such new approaches.

KEYWORDS: Hepatitis B virus; antiviral therapy.; capsid assembly; capsid assembly modulator; core protein; misassembly

PMID:28675991DOI:10.2174/0929867324666170704121800

作者: StephenW 时间: 2017-7-6 17:30

Curr Med Chem。 2017年7月4日。doi：10.2174 / 0929867324666170704121800。 [提前印刷]
乙型肝炎病毒核衣壳组装的小分子抑制剂：治疗慢性HBV感染的新方法。
杨L1，卢M2。
作者信息

1
中国科学院上海药物研究所药物研究国家重点实验室免疫药理实验室，上海。中国。
2
埃森大学埃森大学医院埃里森大学病毒学研究所。德国。

抽象

乙型肝炎病毒（HBV）感染仍然是全球的主要健康问题。目前用于治疗慢性HBV感染的抗病毒药物未能取得满意的效果。因此，根据HBV分子生物学基础研究的最新进展，开发出新的抗HBV药物是可取的。 HBV核衣壳组装现在被认为是抗HBV治疗的潜在目标。结构和功能分析提供了HBV核衣壳组分的分子相互作用的基本见解。在临床Ⅰ期开发并部分测试了HBV核衣壳组装的小分子调节剂的原型。在本综述中，HBV分子生物学的最新进展和基于病毒核衣壳中断的抗HBV治疗抑制剂的方法将总结防止组装或归纳错误组装。我们将根据这种新方法讨论抗HBV治疗的未来概念。

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关键词：

乙型肝炎病毒抗病毒治疗衣壳装配衣壳装配调制器;核心蛋白;误装

结论：
28675991
DOI：
10.2174 / 0929867324666170704121800

作者: kite2002005 时间: 2017-7-8 23:37

说的容易，做的难，靶向目标一定要是核心，有效，而且要彻底

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