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Liver International
Accepted Article (Accepted, unedited articles published online and citable. The final edited and typeset version of record will appear in future.)
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1 Department of Infectious Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
2 Ministry of Education Key Laboratory of Systems Biomedicine, Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai, China
3 Research Center for Medical Glycoscience, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Ibaraki, Japan
4 Department of Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
5 Translational Medicine Research Center, Ruijin Hospital North, Shanghai Jiao Tong University School of Medicine, Shanghai, China
6 Collaborative Innovation Center of Systems Biomedicine, Shanghai, China
† These authors contributed equally to this work
* Corresponding Authors:
Yan Zhang, Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University,800 Dong Chuan Road, Minhang, Shanghai 200240, China
Tel.: +86-21-34206778; E-mail: [email protected]
Xinxin Zhang, Department of Infectious Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
Tel.: +86-21-64370045; E-mail: [email protected]
This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record. Please cite this article as doi: 10.1111/liv.13188
Keywords:
Wisteria floribunda agglutinin;Mac-2 binding protein;liver fibrosis;chronic hepatitis B
Abstract
Background & Aims
Accurately evaluation of liver fibrosis is crucial for predicting progression of chronic hepatitis B virus (HBV) infection. We assessed the utility of a novel fibrosis glycobiomarker Wisteria floribunda agglutinin-positive Mac-2 binding protein (WFA+-M2BP) for evaluating liver fibrosis and disease progression in patients with chronic HBV infection.
Methods
We enrolled 774 patients with chronic HBV infection, with or without fibrosis, diagnosed by liver biopsy/FibroScan. Patients who underwent liver biopsy (n=297) were divided into training (n=221) and validation (n=76) groups. Serum WFA+-M2BP values were measured and compared with FIB-4 index, aspartate aminotransferase(AST) to platelet ratio (APRI), and AST to alanine aminotransferase ratio (AAR) using receiver operating characteristic (ROC) analysis.
Results
Serum WFA+-M2BP levels increased significantly with fibrosis progression (P<0.0001). Area under the ROC curve of WFA+-M2BP for diagnosing significant fibrosis was higher than that of FIB-4 (P=0.198), APRI (P=0.017), and AAR (P<0.001), with sensitivity and specificity in the training set of 60.5% and 79.8%; and validation set of 59.5% and 82.1%, respectively. Serum WFA+-M2BP levels were significantly correlated with FibroScan values (P<0.0001), and improved the accuracy of FibroScan in assessing significant fibrosis. Changes in WFA+-M2BP levels were parallel with those in FibroScan values during nucleot(s)ide analogues therapy in patients with chronic HBV infection.
Conclusions
WFA+-M2BP is an accurate serum indicator for assessing early stages of liver fibrosis, and may monitor regression of fibrosis during the treatment of chronic HBV infection. WFA+-M2BP provides a simple and reliable alternative or complementary method to liver biopsy and FibroScan.
This article is protected by copyright. All rights reserved. 作者: StephenW 时间: 2016-6-17 17:59