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标题: 模型验证的肝癌患者：香港肝癌的比较与巴塞罗那临床肝癌 [打印本页]

作者: StephenW 时间: 2015-9-11 15:17 标题: 模型验证的肝癌患者：香港肝癌的比较与巴塞罗那临床肝癌

European Journal of Gastroenterology & Hepatology:
October 2015 - Volume 27 - Issue 10 - p 1180–1186
         doi: 10.1097/MEG.0000000000000418
Original Articles: Liver Cancer

  Validation of models in patients with hepatocellular carcinoma:  comparison of Hong Kong Liver Cancer with Barcelona Clinic Liver Cancer staging system in a Chinese cohort

Yan, Xiaopenga; Fu, Xua; Cai, Chuangb; Zi, Xuejianb; Yao, Huia; Qiu, Yudonga

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[/url]Abstract

Objective: Accurate staging information is necessary to determine the prognosis of patients with hepatocellular carcinoma (HCC) and to guide subsequent patient management. This study aims to investigate the prognostic performance of the Hong Kong Liver Cancer (HKLC) classification in a Chinese cohort of HCC patients.

Methods: A total of 668 HCC patients between 2003 and 2012 were included. Performances of the HKLC and the Barcelona Clinic Liver Cancer (BCLC) system were compared using Akaike information criterion (AIC), concordance-index (c-index), and area under the receiver operating characteristic curve (AUC). Independent prognostic factors of survival were identified using univariate and multivariate analyses.

Results: Independent predictors of survival were Child–Pugh grade (P=0.009), lactate dehydrogenase (P<0.001) and albumin (P=0.001) levels, tumor location (P=0.032), tumor number (P<0.001), tumor size (P<0.001), and vascular invasion (P<0.001). Discriminatory ability was shown to be better for HKLC (AUC at 1, 3, and 5 years were 0.740, 0.695, and 0.615, respectively) than BCLC (AUC at 1, 3, and 5 years were 0.622, 0.569, and 0.548, respectively). On the basis of AIC and c-index, HKLC had a higher predictive power for survival (AIC=4709.480, c-index=0.805) than BCLC (AIC=4852.708, c-index=0.717).

Conclusion: In our selected patient population, whose main etiology was hepatitis B, the HKLC system was more suitable for predicting prognosis in a Chinese cohort of HCC patients than the BCLC classification.

作者: StephenW 时间: 2015-9-11 15:17

欧洲胃肠病学和肝病学：
2015年10月 - 27卷 - 10期 - P 1180-1186
DOI：10.1097 / MEG.0000000000000418
原创文章：肝癌
模型验证的肝癌患者：香港肝癌的比较与巴塞罗那临床肝癌分期系统在中国人群

燕，Xiaopenga;富，随感;蔡，Chuangb;子，Xuejianb;姚明，垂耳鸦;邱Yudonga
折叠盒
抽象的

目标：准确的分期信息是必要的，以确定患者的肝细胞癌（HCC）的预后，指导后续的病人管理。本研究旨在探讨在肝癌患者的中国队列香港肝癌（HKLC）分类的预测性能。

方法：668 2003至2012年间肝癌患者都包括在内。所述HKLC和巴塞罗那诊所肝癌（BCLC）系统性能的使用ROC曲线（AUC）下的赤池信息准则（AIC），一致性指数（C指数），和面积进行比较。被确定使用单因素和多因素分析生存的独立预后因素。

结果：生存的独立预测因子Child-Pugh分级级（P = 0.009），乳酸脱氢酶（P <0.001），白蛋白（P = 0.001）水平，肿瘤部位（P = 0.032），肿瘤数目（P <0.001），肿瘤尺寸（P <0.001），血管侵犯（P <0.001）。区分能力被证明是更好的为HKLC（AUC在1，3和5年为0.740，0.695，和0.615，分别）比BCLC（AUC在1，3和5年为0.622，0.569，和0.548，分别）。上AIC和C指数的基础上，HKLC有较高的预测能力的生存（AIC = 4709.480，C指数= 0.805）比BCLC（AIC = 4852.708，C指数= 0.717）。

结论：在我们选择的患者群体，其主要病因是乙型肝炎，所述HKLC系统更适于在HCC患者比BCLC分类的中国队列预测预后。

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