Serum Levels of Hepatitis B Surface Antigen Predict Severity of Fibrosis in Patients With E Antigen-Positive Chronic Hepatitis B
Patrick Marcellincorrespondenceemail
, Michelle Martinot-Peignoux
, Tarik Asselah
, Richard Batrla
, Diethelm Messinger
, Vivien Rothe
, George Lau
, Yun-Fan Liaw
Published Online: December 23, 2014
Article has an altmetric score of 2
DOI: http://dx.doi.org/10.1016/j.cgh.2014.12.017 |
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Publication History
Published Online: December 23, 2014
Background & Aims
Noninvasive techniques are needed to assess hepatic fibrosis in patients with chronic hepatitis B. We developed a scoring system to determine the degree of fibrosis in patients with genotype B or genotype C hepatitis B virus (HBV) infection and positive for the hepatitis B e antigen.
Methods
We performed a retrospective study to identify baseline variables associated with the severity of fibrosis (METAVIR scores, F0–F4) in a large phase 3 clinical trial of predominantly Asian patients (n = 710), using multivariate logistic regression analyses. Significant variables were used to construct predictive models using optimal cut-off values. The final model was validated in similar patients from a large phase 4 clinical trial (n = 465).
Results
We developed 2 prediction scoring systems (PSs). PS1 analyzed data on HBV genotype (B vs C), patient age (<30 vs ≥30 y), level of hepatitis B surface antigen (≤17,500 vs >17,500 IU/mL), and level of alanine aminotransferase (≤3-fold vs >3-fold the upper limit of normal). PS2 analyzed data on only age and level of hepatitis B surface antigen. PS1 identified patients with F0 to F1 vs F2 to F4 fibrosis with more than 87% specificity and a positive predictive value greater than 75; it identified patients with F0 to F2 vs F2 to F4 fibrosis with approximately 95% specificity and a positive predictive value (PPV) of approximately 97%. PS2 identified patients with F0 to F1 fibrosis with less accuracy than PS1, but identified patients with F0 to F2 fibrosis with an almost identical level of sensitivity and PPV.
Conclusions
We developed a simple scoring system to determine the severity of fibrosis in patients with genotypes B or C HBV infection who are hepatitis B e antigen positive. Our system differentiated patients with no or mild fibrosis (F0–F1) from those with marked or severe (F2–F4) fibrosis with a high PPV. The high level of specificity for the identification of nonsevere fibrosis (F0–F2) limits the risk of overlooking patients with severe fibrosis (F3–F4). 作者: StephenW 时间: 2015-8-6 10:59