1Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Instituto de Salud Carlos III, Madrid, Spain; Liver Unit, Department of Internal Medicine, Hospital Universitari Vall d'Hebron and Universitat Autònoma de Barcelona, Barcelona, Spain. Electronic address: [email protected].
2Liver Unit, Department of Internal Medicine, Hospital Universitari Vall d'Hebron and Universitat Autònoma de Barcelona, Barcelona, Spain.
3Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Instituto de Salud Carlos III, Madrid, Spain; Liver Pathology Unit, Departments of Biochemistry and Microbiology (Virology Unit) Hospital Universitari Vall d'Hebron and Universitat Autònoma de Barcelona, Barcelona, Spain.
4Pathology Department, Hospital Universitari Vall d'Hebron and Universitat Autònoma de Barcelona, Barcelona 08035, Spain.
5Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Instituto de Salud Carlos III, Madrid, Spain; Liver Unit, Department of Internal Medicine, Hospital Universitari Vall d'Hebron and Universitat Autònoma de Barcelona, Barcelona, Spain.
"changes in HBV genotype" - http://www.sciencedirect.com/sci ... i/S1201971210024239
"Due to the lack of proof-reading activity of DNA- and RNA-dependent DNA polymerase, mis-incorporations of nucleotides occur during viral replication. The rate of nucleotide substitution per site is estimated to be 1.4–3.2 × 10^(−5) per year.[7] and [8] This has led to the emergence of HBV genotypes and subgenotypes. At least eight different genotypes (A–H) have been identified that differ in more than 8% of the genome, while subgenotypes differ by at least 4%."