P0550
THE IMPACTS OF BASELINE CLINICAL CHARACTERISTICS AND
HEPATITIS B VIRUS MUTATIONS ON CURATIVE EFFECTS OF
CHRONIC HEPATITIS B TREATED WITH NOVAFERON
W. Daxian1, T. Deming1. 1Department of Infectious Diseases, Xiangya
Hospitalo of Central South University, Changsha, China
E-mail: [email protected]
Background and Aims: Novaferon, which is a new type of IFN, had
approved by State Food and Drug Administration (SFDA) for clinical
trials of new drugs on CHB therapy in 2009. To assess the impacts of
baseline clinical characteristics of patients with chronic hepatitis B
(CHB) and baseline hepatitis B virus (HBV) gene mutations on
curative effects of CHB treated with Novaferon.
Methods: Enrolled patients accepted Novaferon monotherapy for
24 weeks and follow up for 12 weeks. Body mass index (BMI) of
patients, genotype, basal core promoter (BCP) and precore (PC),
reverse transcriptase (RT), S region variants of HBV were
determined prior to Novaferon treatment. Aminotransferase (ALT),
Hepatitis B e antigen (HBeAg), HBVDNA, Hepatitis B surface
antigen (HBsAg) were determined at the beginning of treatment
and 12 weeks after treatment. Then the present study evaluated
the influence of age, gender, genotype, BMI, baseline ALT, HBeAg,
HBV-DNA, HBsAg titer as well as BCP, PC, RT and S region variants
on curative effects of chronic hepatitis B treated with Novaferon.
Results: Results In total of 126 CHB patients who finished the
treatedment and follow-up, 38.9% obtained virological response
and 32.5%, 25.4%, 44.4%, 23.8% obtained HBeAg clearence, HBeAg
seroconversion, biochemical response and combined response
respectively. The baseline DNA level of virological response group
was significantly lower than no-virological response group; the
baseline ALT level were significantly higher in HBeAg clearence
group and HBeAg seroconversion group; female and lower BMI
level was prone to acquired biochemical response. Stepwise logistic
regression analysis showed that PC-P159T (ntC2288A), BCP-N118T
(ntA1726C), BCP-L134L (ntA1775C/G/T) were independent influence
factors for virological response. The frequencies of PC-G182C
(ntG2357T) was significantly higher in groups with HBeAg clearance
group and PC-S64A/T (ntT2003G/A), PC-W28STOP (ntG1896A) was
significantly higher in HBeAg seroconversion groups, combined
response respectively.
Conclusions: Conclusions Novaferon was an effective therapeutic
drug for CHB patients, different response type was influenced by
different clinical characteristics and mutations. Baseline mutations
screening could predict curative effect of Novaferon efficiently and
offered the optimal drugs for CHB patients. 作者: StephenW 时间: 2015-4-24 17:15