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Issue
Cover image for Vol. 34 Issue 10
Liver International
Author Information
1 University of Strasbourg, IPHC, Strasbourg, France
2 CNRS, UMR 7178, Strasbourg, France
3 Anschutz Health and Wellness Center, University of Colorado Anschutz Medical Campus, Aurora, CO, USA
4 CARMEN, INSERM U1060, University of Lyon 1, INRA1235, CRNH-RA, Oullins, France
5 CNES, Paris, France
† F. Rudwill and A. Bergouignan contributed equally to this work as first authors.
* Corresponding author and person to whom reprint request should be addressed:
Chantal Simon, MD
Service d'Endocrinologie, Diabète, Nutrition
Centre Hospitalier Lyon Sud
165 Chemin du Grand Revoyet
69600 Oullins, France
Phone: +33426235917 - Fax: +33426235916
e-mail: [email protected]
This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record. Please cite this article as doi: 10.1111/liv.12743
Abstract
Background
Physical inactivity leads to a cluster of metabolic disorders that have been associated with non-alcoholic fatty liver diseases.
Aim
To test whether physical inactivity increases hepatic biomarkers of non-alcoholic fatty liver diseases.
Methods
Sixteen normal-weight healthy women (body mass index=21.2±0.5 kg.m−2) were studied under controlled energy balance conditions during a previous 60-day bed-rest with (n=8) or without (n=8) a combined aerobic/resistive exercise protocol. We retrospectively used stored samples to measure plasma hepatic markers, i.e. steatosis-related alanine and aspartate transaminases, cytokeratin 18 and angiopoietin-like 3, at baseline, after 30 and 60 days of bed-rest. Fasting insulin and triglycerides were measured at baseline and after 30 days of bed-rest. Two indexes were calculated, one combining alanine, aspartate transferase and cytokeratin 18 and another cytokeratin 18, homeostasis model assessement–insulin resistance and aspartate transferase.
Results
Sixty days of bed-rest increased all hepatic markers (p<0.05 for all) and the two indexes (p<0.01 for both). Exercise significantly reduced the elevation in aspartate transaminase, cytokeratin 18 and both indexes (p<0.02 for all) but not the increase in alanine transferase and angiopoietin-like 3. Changes between baseline and 30 days of bed rest in triglycerides were positively associated with changes in aspartate transferase (R2=0.28, p=0.04) suggesting a role of hypertriglyceridemia in the alteration of liver metabolism under inactive conditions.
Conclusions
Physical inactivity increases, independent of fat mass, hepatic markers of steatosis and steatohepatitis. Regular exercise can limit these physical inactivity-induced metabolic alterations. Future studies need to elucidate the underlying mechanisms.
This article is protected by copyright. All rights reserved. 作者: StephenW 时间: 2014-11-27 19:45