1851
Tenofovir Disoproxil: Effective and Safe in Prevention of Mother-to-child Transmission of Hepatitis B Virus
Hongfei Huang, Quanxin Wu, Yuming Wang;
Department of Infectious Diseases, Southwest Hospital Third Military Medical University, Chongqing, China
Background Mother-to-child transmission (MTCT) of hepatitis B virus(HBV) still remains a world concerned question. Previous studies have demonstrated the effectiveness of telbivudine (LdT) and lamivudine (LAM) in pregnancy, but there were few data about tenofovir (TDF), also it is a controversal problem on the choice of antiviral drugs and the appropriate time to start therapy. Purpose To evaluate the safety and reliability of tenofovir in preventing mother-to-child transmission of HBV during pregnancy. Methods We totally enrolled 38 HBV infected pregnant women with HBsAg and HBeAg positive since 8/2009 until 5/2013. Among these patients, 21 women were treated with TDF (300mg/d) alone; 11 were treated with TDF (300mg/d) +LDT (600mg/d), while 6 were treated with TDF (300mg/d) +LAM (100mg/d) during pregnancy. All the babies were injected with hepatitis B vaccine and immunoglobulin according to the standard protocal after birth. Mothers co-infected with other liver diseases were excluded from the study. Results In our study, 13 mothers started treatment at the first trimester (0-11 weeks); and 4 began treatment at the second trimester (15-24 weeks); while 21 started treatment at the third trimester (28-39 weeks). Five mothers were with ALT elevation before treatment which ranged from 1.8×ULN to 12.2×ULN and 2 of them decreased to normal level at delivery. All the infants cordblood were detected negative for HBV DNA and born with no congenital diseases. All babies were detected negative for HBsAg and HBV DNA at 20-48 weeks . Conclusion It is safe and effective by using tenofovir in prevent mother-to-child transmission of HBV during the whole pregnancy.
Disclosures:
The following people have nothing to disclose: Hongfei Huang, Quanxin Wu, Yuming Wang 作者: StephenW 时间: 2014-10-15 06:49