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标题: AASLD2014:25（OH）D在南中国的慢性HBV感染者高25（OH）D 3的患者 [打印本页]

作者: StephenW 时间: 2014-10-12 05:21 标题: AASLD2014:25（OH）D在南中国的慢性HBV感染者高25（OH）D 3的患者

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The prevalence of 25(OH)D3 in the patients of South China with chronic HBV infection and high 25(OH)D3 related with low HBV DNA viral load
Guoli Lin, Yunlong Ao, Xin-Hua Li, Yuankai Wu, Yusheng Jie, Hong
Shi, Xiangyong Li, Fangji Yang, Shu-ru Chen, Yutian Chong; The
Department of Infectious Disease, The Third Affiliated Hospital of
Sun Yat-sen University, Guangzhou, China
Vitamin D is an important immune modulator in viral hepatitis,
including infection with hepatitis B virus(HBV). China is the
area with high endemicity, however the relationship between
vitamin D metabolism and chronic hepatitis B is less well analyzed in Chinese people with chronic HBV infection. Therefore we quantified 25-hydroxyvitamin D [25(OH)D3] serum levels in 556 subjects with chronic HBV infections, including 108 subjects with hepatic cirrhosis(cirrhosis group) and 448 subjects without the clinical proofs of hepatic cirrhosis(hepatitis group), they were all from South China. The 25(OH)D3 deficiency rate was 35.3%(196/556), insufficient rate was 31.3%(174/556), the level within the normal rage was 33.4%(186/556), there was no difference between the hepaitis group and cirrhosis group(p=0.7517). The serum levels of 25(OH)D3 was not related with the measured value of the Fibroscan(r=-0.1063, p=0.2712). 25(OH)D3 was not related with Age (p=0.3698), but related with gender, male was higher than female (p<0.0001). Regarding the relationship between HBVDAN and 25(OH)D3 we found that HBVDNA and 25(OH)D3 was negative correlation (r=-0.3005, p<0.0001), and the serum levels of 25(OH)D3 were different between the high load HBVDNA and low load HBVDNA.(p<0.01). finally, 25(OH)D3 and HBV DNA showed seasonal fluctuations. Conclusions: the insufficiency and deficiency of 25(OH)D3 were
common among the subjects with chronic infection of HBV in South China. There was no difference between different age groups, but there was difference between male and female in
25(OH)D3 serum levels. Lower 25(OH)D3 serum levels were associated with high levels of HBV replication in patients with chronic hepatitis B.

作者: StephenW 时间: 2014-10-12 05:22

1695
25（OH）D在南中国的慢性HBV感染者高25（OH）D 3的患者的患病率，低HBV DNA病毒载量相关
国力林，云龙岙，李新华，元凯吴渝生杰，康
施，李乡勇，防己杨舒茹陈，玉田冲;该
传染病，附属第三医院科
中山大学大学，中国广州
维生素D是在病毒性肝炎的重要的免疫调节剂，
包括感染乙肝病毒（HBV）。中国是
与高流行地区，但是之间的关系
维生素D代谢和慢性乙型肝炎是中国人的慢性HBV感染者也少了分析。因此，我们量化的25羟基维生素D[25（OH）D]的556科目慢性乙肝病毒感染，包括108科肝硬化（肝硬化组）和448例无肝硬化（肝炎组）的临床证明血清，他们均来自中国南方。 25（OH）D缺乏率为35.3％（五百五十六分之一百九十六），速率不足为31.3％（五百五十六分之一百七十四），在正常范围内风靡一时的水平为33.4％（556分之186），又出现了hepaitis没有什么区别组和肝硬化组（p=0.7517）。 25（OH）D 3的血清水平是不相关的Fibroscan的的测量值相关（r =-0.1063，p值=0.2712）。 25（OH）D与患者年龄（P =0.3698）相关，但与性别有关，男性明显高于女性（P <0.0001）。关于HBVDAN和25（OH）D 3之间的关系，我们发现，HBVDNA和25（OH）D3是负相关（r=-0.3005，p <0.0001），和25（OH）D 3的血清水平的高之间的不同HBVDNA负荷及低负荷HBVDNA（P <0.01）。最后，25（OH）D 3和HBV DNA呈季节性波动。结论：该功能不全和25（OH）D3的缺乏是其中乙肝病毒慢性感染者共同中国南方。有不同年龄之间无明显差异团体，但有男性和女性之间的差异 25（OH）D 3的血清水平。下部25（OH）D 3的血清水平
与高水平乙型肝炎病毒复制的患者相关联的慢性乙型肝炎.

作者: 肝肠欲断 时间: 2014-10-12 10:24

StephenW先生辛苦了！早晨5点就起来发帖子了

，是不是说维生素D代谢和慢性乙型肝炎DNA的高低有关联？

作者: StephenW 时间: 2014-10-12 16:05

回复肝肠欲断的帖子

谢谢. 悉尼时间提前3小时你的时间.

是, 血清维生素D水平和慢性乙型肝炎hbvDNA的高低有关联. 是引起或导致(cause or effect)尚不清楚.
多数乙肝患者缺乏维生素D, 维生素D具有免疫效果.

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