Compromised function of natural killer cells in acute and chronic viral hepatitis
Sebastian Lunemann1,2,
David F. G. Malone2,
Julia Hengst1,2,
Kerstin Port1,
Jan Grabowski1,
Katja Deterding1,
Antoaneta Markova1,
Birgit Bremer1,
Verena Schlaphoff1,
Markus Cornberg1,
Michael P. Manns1,
Johan K. Sandberg2,
Hans-Gustaf Ljunggren2,
Niklas K. Björkström2,3 and
Heiner Wedemeyer1
+ Author Affiliations
1Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, 30161 Hannover , Germany
2Center for Infectious Medicine, Department of Medicine, Karolinska Institutet, S-14186 Stockholm, Sweden
3Liver Immunology Laboratory, Department of Medicine, Karolinska Institutet, S-14186 Stockholm, Sweden
Background. Natural killer (NK) cells are an integral part of the innate immune system. They have been suggested to play an important role in both defense against viral hepatitis and the pathogenesis of other liver diseases.
Methods. NK cells from 134 individuals including patients with acute hepatitis B and C as well as chronic hepatitis B, C, and delta (D) patients were studied.
Results. Infection with viral hepatitis was associated with increased frequencies of NK cells in the peripheral blood; that NK cells showed a less activated phenotype and were compromised in cytolotytic function and cytokine production in all viral hepatitis infections: Hepatitis virus infections did not alter NK cell differentiation and the activity and severity of liver disease were reflected by alterations of NK cell surface receptors as demonstrated by principal component analysis.
Conclusion. NK cell phenotypic and functional alterations can equally be observed in HBV, HCV, and HDV infections. Instead, patterns of NK cell alterations differ in acute and chronic infections. Thus, our data suggest a common mechanism in the alteration of NK cell phenotype and function with unique variations that depend on disease activity rather than virus-specific factors.
Received May 27, 2013.
Revision received August 9, 2013.
Accepted September 6, 2013.
作者: StephenW 时间: 2013-10-25 17:45
自然杀伤细胞的功能受到损害急性和慢性病毒性肝炎
塞巴斯蒂安Lunemann1 2 ,
戴维· G. Malone2 ,
朱莉娅Hengst1 2 ,
端口1凯尔斯丁,
Jan Grabowski1的,
卡佳Deterding1
令Antoaneta Markova1
吉特Bremer1 ,
韦雷Schlaphoff1 ,
马库斯Cornberg1
迈克尔P. Manns1 ,
约翰· K. Sandberg2 ,
汉斯 - 古斯塔夫Ljunggren2 ,
尼克拉斯· K. Björkström2 3
海纳Wedemeyer1的
+作者所属机构
1汉诺威医学院胃肠病,肝病,内分泌科, 30161汉诺威,德国
, S - 14186 ,瑞典斯德哥尔摩卡罗林斯卡医学院医学系传染病医学, 2Center
S - 14186 ,瑞典斯德哥尔摩卡罗林斯卡医学院医学系,免疫学实验室3Liver ,