Coffee Reduces Risk for Hepatocellular Carcinoma: An Updated Meta-analysis
Francesca Bravi
,
Cristina Bosetti
,
Alessandra Tavani
,
Silvano Gallus
,
Carlo La Vecchiaemail address
Department of Epidemiology, IRCCS – Istituto di Ricerche Farmacologiche “Mario Negri,” Milan, Italy
Department of Clinical Sciences and Community Health, Università degli Studi di Milan, Milan, Italy
published online 08 May 2013.
Background & Aims
Coffee consumption has been suggested to reduce the risk for hepatocellular carcinoma (HCC). We performed a meta-analysis of epidemiological studies to provide updated information on how coffee drinking affects HCC risk.
Methods
We performed a PubMed/MEDLINE search of the original articles published in English from 1966 through September 2012, on case-control or cohort studies that associated coffee consumption with liver cancer or HCC. We calculated the summary relative risk (RR) for any, low, and high consumption of coffee vs no consumption. The cut-off point for low vs high consumption was set to 3 cups per day in 9 studies and 1 cup per day in 5 studies.
Results
The summary RR for any coffee consumption vs no consumption was 0.60 from 16 studies, comprising a total of 3153 HCC cases (95% confidence interval [CI], 0.50–0.71); the RRs were 0.56 from 8 case-control studies (95% CI, 0.42–0.75) and 0.64 from 8 cohort studies (95% CI, 0.52–0.78). Compared with no coffee consumption, the summary RR was 0.72 (95% CI, 0.61–0.84) for low consumption and 0.44 (95% CI, 0.39–0.50) for high consumption. The summary RR was 0.80 (95% CI, 0.77–0.84) for an increment of 1 cup of coffee per day. The inverse relationship between coffee and HCC risk was consistent regardless of the subjects’ sex, alcohol drinking, or history of hepatitis or liver disease.
Conclusions
From this meta-analysis, the risk of HCC is reduced by 40% for any coffee consumption vs no consumption. The inverse association might partly or largely exist because patients with liver and digestive diseases reduce their coffee intake. However, coffee has been shown to affect liver enzymes and development of cirrhosis, and therefore could protect against liver carcinogenesis. 作者: StephenW 时间: 2013-10-24 18:03
据美国胃肠病协会官方临床实践类杂志《Clinical Gastroenterology and Hepatology》上发表的一项最新的meta分析显示,喝咖啡能将发生肝细胞癌(HCC)这一最常见类型肝癌风险降低约40%。同时一些数据进一步证实每天三杯咖啡能够将患肝癌的风险降低超过50%。具体内容:Clin Gastroenterol Hepatol 2013 May 6.
“我们的研究证实了先前的观点,即咖啡有益健康,对肝脏更为如此,”该研究的作者,来自马里奥·内格里药理学研究所的米兰大学临床科学及社区卫生系医学博士Carlo La Vecchia这么说。“咖啡对肝癌的这一有利影响可能与由于其已经证实的对糖尿病预防作用,或者其对肝硬化或肝脏酶类的益处有关。糖尿病是肝癌的一个危险因素。”