Title | Inhibition of Hepatitis B Virus Replication In Vivo by A Novel non-nucleosidic compound |
Speaker: | Xueyan Wang |
Author: | X. Wang*, D. Jiang, H. Zhang, F. Liu, H. Zhang, X. Xie, L. Wei, H. Chen |
Affiliation: | Peking University People's Hospital, Peking University Hepatology Institute, Beijing, China. *[email protected] |
Background and aims: Chronic hepatitis B virus (HBV) infection is a major cause of liver disease. The development of new antiviral compounds suitable for monotherapy or combination therapy for HBV infections is highly desired. GH-1, a member of a class of heteroaryldihydropyrimidines (HAP), was discovered a novel and highly specific anti-viral principle in vitro. Here, we reported the antiviral activity of GH-1 in transgenic mice expressing HBV. |
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