标题: High Rates of Viral Suppression following Long-Term Entecavir Treatment of Asian [打印本页] 作者: StephenW 时间: 2012-4-10 19:56 标题: High Rates of Viral Suppression following Long-Term Entecavir Treatment of Asian
AbstractThere are limited data on the effects of long-term entecavir therapy in Asian patients with chronic hepatitis B (CHB). We performed a post-hoc analysis of 94 Asian, hepatitis B e antigen-positive (HBeAg+), nucleos(t)ide analog-naïve patients who received 5 years of therapy with entecavir (up to 2 years in study ETV-022 and the remainder in study ETV-901). Among patients completing Week 240, 95% (63/66) had levels of hepatitis B virus DNA <300 copies/mL, and 76% (50/66) had normalized levels of alanine aminotransferase. In addition to patients who achieved a serologic response during ETV-022, another 40% (26/65) achieved HBeAg loss and 18% (12/65) underwent HBeAg seroconversion after 5 years of therapy with entecavir. No resistance to entecavir was detected and the safety profile was consistent with previous reports. The long-term efficacy and safety of entecavir are therefore comparable between Asians and the overall population of HBeAg+ patients with CHB. 作者: StephenW 时间: 2012-4-10 19:56