我不是专家。超抗原的概念很有意思。我谷歌超抗原。我不认为B型肝炎病毒表达任何超抗原（s抗原，e抗原，核心抗原）。 Superantigens (SAgs) are a class of antigens which cause non-specific activation of T-cells resulting in oligoclonal T cell activation and massive cytokine release. SAgs can be produced by pathogenicmicrobes (including viruses, mycoplasma, and bacteria)[1] as a defense mechanism against the immune system.[2] Compared to a normal antigen-induced T-cell response where .001-.0001% of the body’s T-cells are activated, these SAgs are capable of activating up to 20% of the body’s T-cells.[citation needed] Furthermore, Anti-CD3 and Anti-CD28Antibodies (CD28-SuperMAB) have also shown to be highly potent superantigens (and can activate up to 100% of T cells).
The large number of activated T-cells generates a massive immune response which is not specific to any particular epitope on the SAg thus undermining one of the fundamental strengths of the adaptive immune system, that is, its ability to target antigens with high specificity. More importantly, the large number of activated T-cells secrete large amounts of cytokines (the most important of which is TNF-alpha). TNF-alpha is particularly important as a part of the body's inflammatory response, and in normal circumstances (where it is released locally in low levels) helps the immune system defeat pathogens. However when it is systemically released in the blood and in high levels (due to mass T-cell activation resulting from the SAg binding), it can cause severe and life-threatening symptoms, including shock and multiple organ failure.
不过，我觉得你说得对 - "机体把乙肝病毒的抗原当成了自己"
HBeAg被认为是耐受性tolerogenic（我不知道它是如何诱导免疫耐受）。它是可溶的(soluble)，可穿过胎盘。
因此B型肝炎病毒有两个武器打败我们的免疫系统：
1。 e抗原生产的，一个复制没有需要的蛋白质;
2。生产S抗原过剩的数量，远远超过复制的需要.
The HbeAg is considered to be tolerogenic (I don't know how it induces immune tolerance). It is soluble and can cross the placenta.
So the hepatitis B virus has two weapons to defeat our immune system:
1. production of e antigen, a protein that is not needed for replication to induce tolerance;
2. production of s antigen in excess quantity, far more than is needed for replication to suppress our immune system.
[attach]272162[/attach] 作者: 0914 时间: 2012-1-12 17:59