标题: Your Address, Ethnicity and Drug Use Determine Your HBV Genotype [打印本页] 作者: liver411 时间: 2011-11-23 08:17 标题: Your Address, Ethnicity and Drug Use Determine Your HBV Genotype
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Your Address, Ethnicity and Drug Use Determine Your HBV Genotype
The U.S. Centers for Disease Control and Prevention analyzed blood samples from 614 patients who experienced acute, or new, hepatitis B infections in six counties nationwide that participate in the Sentinel Counties Study of Acute Viral Hepatitis between 1999 and 2005.
Researchers wanted to know which hepatitis B strains or genotypes were spreading most rapidly in this sample population.
There are eight genotypes (A-H), and each genotype evolved in specific geographic areas of the world. For example, genotype A is prevalent in northwestern Europe, North America, and Africa; genotypes B and C are common in Asia; genotype D is most frequently found in the Mediterranean area; genotype E is prevalent in Africa; genotype F is prevalent in the aboriginal populations of South America; genotype G is found in Europe and the U.S., and genotype H is prevalent in the Amerindian populations of Central America.
As expected, all HBV genotypes are found in the United States, with genotype A commonly found in white and African-American patients and genotypes B and C found in Asian-Americans.
According to the report on new HBV infections, published in the August 2011 issue of the journal of Clinical Infectious Diseases:
75% of new HBV infections were genotype A
18% were infected with genotype D
Genotype A infections (compared with genotype D) were five times greater among African-Americans than among Hispanics.
The odds of infection with genotype A were 49-, 8-, and 4-times higher in patients from Jefferson County (Alabama), Pinellas County (Florida), and San Francisco (California), respectively, than among those living in Denver County (Colorado).
Genotype A was less common among recent injection drug users than it was among non-injection drug users.
Researchers concluded that ethnicity, geographic residence, and injecting drug use greatly determined a hepatitis B patient’s genotype.