标题: hepatitis B e antigen-negative chronic hepatitis B patients with stringent cessa [打印本页] 作者: StephenW 时间: 2011-11-17 10:34 标题: hepatitis B e antigen-negative chronic hepatitis B patients with stringent cessa
Arch Virol. 2011 Nov 15. http://www.ncbi.nlm.nih.gov/pubmed/22080196
A prospective clinical study in hepatitis B e antigen-negative chronic
hepatitis B patients with stringent cessation criteria for adefovir. Ha M,
Zhang G, Diao S, Lin M, Sun L, She H, Kuan C, Shen L, Huang C, Shen W,
Huang Z. Department of Infectious Diseases and Hepatology, Shanghai No 7
hospital, Pudong Gaoqiao Datong Road 358, Shanghai, 200137, China, [email protected].
Adefovir is usually applied for therapy of chronic hepatitis B (CHB), but
its effectiveness after cessation is still unknown. This study was to
evaluate the effectiveness of adefovir treatment with strict cessation
criteria in hepatitis B e antigen (HBeAg)-negative patients and to identify
potentially important factors. One hundred forty-five HBeAg-negative CHB
patients who had received adefovir treatment for at least 24 months and for
whom serum hepatitis B virus (HBV) DNA had remained undetectable for at
least 18 months before cessation were included. They were followed up
monthly during the first four months and at 3-month or 6-month intervals
thereafter. Patients with ≥10(4) copies of HBV DNA per mL were defined as
relapsed. In total, 95 patients relapsed within the follow-up time, and
more than 93% relapsed within 12 months after adefovir cessation.
Cumulative relapse rates at months 6, 12, 24, 36, 48 and 60 were 53.8%,
61.4%, 65.5%, 65.5%, 65.5% and 65.5%, respectively. Age was the only factor
associated with relapse, with lower relapse rates in younger patients shown
by Cox regression analysis. HBsAg seroconversion occurred in 12 patients,
and none of them relapsed during follow-up. The effectiveness of adefovir
therapy does not persist in HBeAg-negative CHB patients, even when strict
cessation criteria are applied, except for patients aged ≤ 25 years.
HBsAg seroconversion is the ideal endpoint of adefovir treatment.作者: StephenW 时间: 2011-11-17 10:34