标题: Enchanced levels of Apolipoprotein M during HBV infection feedback suppresses HB [打印本页] 作者: StephenW 时间: 2011-9-12 15:31 标题: Enchanced levels of Apolipoprotein M during HBV infection feedback suppresses HB
Enchanced levels of Apolipoprotein M during HBV infection feedback
suppresses HBV replication
Jin-gang Gu, Cheng-liang Zhu, Duo-zhi Cheng, Yan Xie, Fang Liu and Xin Zhou
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Lipids in Health and Disease 2011, 10:154 doi:10.1186/1476-511X-10-154
Published: 29 August 2011
Abstract (provisional)
Background
Chronic liver diseases can interfere with hepatic metabolism of
lipoproteins, apolipoproteins. Hepatitis B virus (HBV) is a major
etiological agent causing acute and chronic liver diseases. Apolipoprotein
M (ApoM) is a high-density lipoprotein (HDL) apolipoprotein and exclusively
expressed in the liver parenchyma cells and in the tubular cells of the
kidney. This study was to determine the correlation between HBV infection
and ApoM expression. Materials and Methods: Serum ApoM levels in patients
with HBV infection and in healthy individuals were measured by ELISA, ApoM
mRNA expression were determined by RT-PCR, and the expression of S and E
proteins of HBV, as well as the synthesis of viral DNA were measured by
ELISA and real-time PCR.
Results
The levels of serum ApoM was significantly elevated in patients as compared
to healthy individuals (P < 0.001), ApoM promoter activity, mRNA and
protein expression were all stimulated in cells transfected with infectious
HBV clone. In addition, ApoM decreases the expression of S and E proteins
of HBV and the synthesis of viral DNA.
Conclusion
Raised ApoM levels in HBV infection may in turn suppress HBV replication,
one of the protective mechanisms of nature.
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