标题: Viral Load, Genotypes, and Mutants in HBV-Related Hepatocellular C [打印本页] 作者: StephenW 时间: 2011-8-17 15:22 标题: Viral Load, Genotypes, and Mutants in HBV-Related Hepatocellular C
Digestive Diseases and Sciences
DOI: 10.1007/s10620-011-1844-2Online First™
Original Article
Viral Load, Genotypes, and Mutants in Hepatitis B Virus-Related
Hepatocellular Carcinoma: Special Emphasis on Patients with Early
Hepatocellular Carcinoma
Chia-Ming Chu, Chen-Chun Lin, Shi-Ming Lin, Deng-Yn Lin and Yun-Fan Liaw
Abstract
Background/Aims
The role of viral factors in the pathogenesis of hepatitis B virus
(HBV)-related hepatocellular carcinoma (HCC) is still inconclusive. Whether
virological features such as viral load or mutants might change with the
progression of HCC remains unknown. A case–control study including
patients with early HCC and HBsAg carriers who are presumed to be at the
minimal potential of HCC as controls might better identify factors
significantly associated with HCC development. Methods Virological features
were compared between 59 patients with early HCC (a solitary tumor of size
≤3 cm) and 101 patients with non-early HCC. A case–control study was
performed by comparing 59 patients with early HCC and 1:2 age-matched
inactive carriers with persistent normal alanine aminotransferase (ALT)
levels. Results HBV DNA levels, HBV genotypes, and the frequency of precore
A1896 and basal core promoter T1762/A1764 mutations showed no significant
difference between patients with early HCC and those with non-early HCC. In
the case–control study, patients with early HCC had significantly higher
HBV DNA levels, and higher frequencies of genotype C HBV and basal core
promoter T1762/A1764 mutation, but a similar frequency of precore A1896
mutation. Multiple logistic regression analysis identified HBV DNA levels
≥2,000 IU/mL and basal core promoter T1762/A1764 mutation as being
independent factors for HCC development. Additionally, there was a
synergistic effect between high viral load and basal core promoter
T1762/A1764 mutation on HCC development. Conclusions Virological features
did not change significantly with the progression of HCC. HBV DNA levels
≥2,000 IU/mL and basal core promoter T1762/A1764 mutation were two
independent viral factors for HCC.
