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标题: [英语,研究] Viral hepatitis: Interleukin 21 has a key role in age-dependen [打印本页]

作者: StephenW    时间: 2011-5-9 19:01     标题: [英语,研究] Viral hepatitis: Interleukin 21 has a key role in age-dependen

本帖最后由 风雨不动 于 2012-4-14 15:19 编辑

Viral hepatitis: Interleukin 21 has a key role in age-dependent response to HBV

Isobel Franks

In humans, the immune response to HBV is age dependent; adults tend to clear the virus, whereas children are more likely to develop chronic infection. From the results of their recent study, Jody Baron and colleagues speculate that interleukin (IL)-21 has a key role in this age-dependent response.

Studying the early immune events of HBV infection in humans is difficult. Baron and her colleagues have developed a mouse model of HBV infection in which differences in viral clearance accurately reflect that seen in humans—young mice fail to clear HBV antigens but adult mice exhibit a robust immune response.

Data from this mouse model show that IL-21 seems to have an important role in determining the immune response to HBV. Adult mice with HBV infection demonstrated increased production of IL-21 in the liver compared with young mice. Furthermore, in adult mice lacking the IL-21 receptor, HBV antigens were able to persist, and these mice had an immune response similar to that seen in the young mice. In humans, IL-21 mRNA levels were increased in patients with acute infection who cleared the virus compared with patients who did not clear the virus.

“We plan to use the model to further understand the differences in the immune responses primed in the young mice as compared to the adult mice, and to identify the cellular and molecular mechanisms that underpin these different immune priming events and different disease outcomes,” concludes Baron. “These studies will identify new potential therapeutic targets to treat HBV infection.”



References and linksORIGINAL RESEARCH PAPER

Publicover, J. et al. IL-21 is pivotal in determining age-dependent effectiveness of immune responses in a mouse model of human hepatitis B. J. Clin. Invest. doi:  10.1172/JCI44198





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作者: StephenW    时间: 2011-5-9 19:03

病毒性肝炎:白细胞介素21具有年龄依赖性反应对HBV的关键作用

伊泽贝尔弗兰克斯

在人类中,乙肝病毒的免疫反应与年龄相关;成年人往往会清除病毒,而儿童更容易发展成慢性感染。从他们最近的研究结果,乔迪男爵和他的同事推测,白细胞介素(IL)-21已经在这个年龄相关性反应的关键作用。

研究人类B型肝炎病毒感染的早期免疫活动是困难的。男爵和她的同事们开发出了乙肝病毒感染小鼠模型中,病毒清除差异准确地反映了人类看到,年轻老鼠不明确的乙肝病毒抗原,但成年小鼠表现出了强烈的免疫反应。

从这个数据表明,小鼠模型的IL - 21似乎在确定对HBV的免疫反应的重要作用。乙肝病毒感染的成年老鼠肝脏中表现出增加的IL - 21的生产比年轻老鼠。此外,在缺乏成人的IL - 21受体的小鼠,乙肝病毒抗原,能够坚持,这些小鼠的免疫反应类似在幼鼠看过。在人类和IL - 21表达水平升高在急性感染病人谁清除的病毒的患者相比,谁没有清除病毒。

“我们计划使用该模型,以进一步了解在年轻小鼠的免疫反应的引物差异相比,成年老鼠,并确定了细胞和分子机制,巩固这些不同的免疫疾病引发的事件和不同的结果,”总结男爵。 “这些研究将确定新的潜在的治疗靶点治疗乙肝病毒感染。”

参考资料和链接

Publicover,学者等。白细胞介素- 21是在决定一个人的北京临床肝炎小鼠模型的年龄相关性免疫反应的有效性的关键。投资。分类号:10.1172/JCI44198




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