| 6 studies meeting the eligibility criteria (1 English,5 Chinese) were included in the meta-analysis; 1 was an international study with a majority of Asian patients. |
| In the combined analysis, significantly more patients taking entecavir achieved undetectable HBV DNA than those taking adefovir (65% vs 36%; relative risk 1.73). |
| More people in the entecavir arms experienced ALT normalization compared with the adefovir arms (71% vs 56%; relative risk 1.25). |
| However, there were no statistically significant differences between entecavir and adefovir recipients with regard to rates of HBeAg clearance (11% vs 13%; relative risk 0.77) or HBeAg seroconversion (6% vs 8%; relative risk 0.74). |